Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEV7FY)

Drug Name
TINGENIN B Drug Info
Synonyms
Tingenin B; 22-Hydroxytingenone; 50656-68-3; (6aS,6bS,8aR,9S,11R,12aS,14aR)-3,9-dihydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-dione; AC1L2JCW; AC1Q6P5G; (6bs,8ar,9s,11r,12as,12bs,14ar)-3,9-dihydroxy-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,11,12,12a,12b,13,14,14a-decahydropicene-2,10(6bh,9h)-dione; CTK4J2949; D:A-Friedo-24,30-dinoroleana-1(10),3,5,7-tetraene-2,21-dione, 3,22-dihydroxy-, (20beta,22beta)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
73147
CAS Number
CAS 50656-68-3
TTD Drug ID
DMEV7FY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Aldose reductase (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epalrestat DM5OGK0 Diabetic neuropathy 8C0Z Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Fidarestat DMZL1I8 Diabetic complication 5A2Y Phase 3 [6]
Ranirestat DMD5QRS Diabetic neuropathy 8C0Z Phase 3 [7]
CONTIGOSIDE B DMX9V8K Thrombosis DB61-GB90 Phase 2/3 [8]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [7]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [9]
LIDORESTAT DMA0RI9 Diabetic complication 5A2Y Phase 2 [10]
QR-333 DMKVIWM Diabetic neuropathy 8C0Z Phase 2 [11]
ADMVA DM819CO Diabetic complication 5A2Y Phase 2 [7]
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Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [18]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [19]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [15]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [21]
Etretinate DM2CZFA Keratosis ED56 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [25]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [28]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Selenium DM25CGV N. A. N. A. Approved [31]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [47]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [53]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [53]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [64]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [65]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Etretinate DM2CZFA Keratosis ED56 Approved [22]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [73]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [40]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [78]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [81]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [83]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Meloxicam DM2AR7L Arthritis FA20 Approved [86]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [2]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Post-Translational Modifications [3]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [3]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Protein Interaction/Cellular Processes [3]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Gene/Protein Processing [2]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Gene/Protein Processing [3]

References

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69 Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
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71 Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
72 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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