Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEXLUR)

Drug Name
(R)-Mevalonate Drug Info
Synonyms (R)-mevalonate; mevalonate; mevalonic acid; (3R)-3,5-dihydroxy-3-methylpentanoate; AC1NRC4P; GTPL3042; CHEBI:36464; CTK4B1152; DTXSID50415347
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5288798
ChEBI ID
CHEBI:36464
TTD Drug ID
DMEXLUR
INTEDE Drug ID
DR2053

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HMG-CoA reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [4]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [5]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [6]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [7]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [8]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [5]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [10]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mevalonate kinase (MVK) Main DME DEAO92K KIME_HUMAN Substrate [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3042).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24.
4 A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis. 2002 Jun;162(2):373-9.
5 Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64.
6 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7 Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203.
8 New dimension of statin action on ApoB atherogenicity. Clin Cardiol. 2003 Jan;26(1 Suppl 1):I7-10.
9 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
10 Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46.