Details of the Drug

General Information of Drug (ID: DM4MDJY)

Drug Name
Fluvastatin
Synonyms
Canef; Cranoc; Fluindostatin; Fluvas; Fluvastatina; Fluvastatine; Fluvastatinum; Lescol; Lescol XL; XU 62320; Canef(TN); Fluvas (TN); Fluvastatin & Primycin; Fluvastatin (INN); Fluvastatin [INN:BAN]; Fluvastatina [INN-Spanish]; Fluvastatine [INN-French]; Fluvastatinum [INN-Latin]; Lescol (TN); Vastin (TN); XU-62320; (+)-(3R,5S)-fluvastatin; (-)-(3S,5R)-fluvastatin; (3R,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5R,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid; (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (Z,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoate; 7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Approved [1]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia, familial combined, LPL related N.A. Approved [1]
Therapeutic Class
Anticholesteremic Agents
Affected Organisms
Humans and other mammals
ATC Code
C10AA04: Fluvastatin
C10AA: HMG CoA reductase inhibitors
C10A: LIPID MODIFYING AGENTS, PLAIN
C10: LIPID MODIFYING AGENTS
C: CARDIOVASCULAR SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 411.5
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 16 mL/min/kg [4]
Elimination
1.5% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 3 hours [4]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.62099 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.0079% [4]
Vd
The volume of distribution (Vd) of drug is 0.35 L/kg []
Water Solubility
The ability of drug to dissolve in water is measured as 50 mg/mL [3]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Acute myocardial infarction Not Available MMP3 OTGBI74Z [6]
Arteriosclerosis Not Available CES1 OT9L0LR8 [6]
Lipids abnormal Not Available ACE OTDF1964 [6]
Myocardial ischaemia Not Available APOE OTFOWL2H [6]
Chemical Identifiers
Formula
C24H26FNO4
IUPAC Name
(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Canonical SMILES
CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
InChI
InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1
InChIKey
FJLGEFLZQAZZCD-MCBHFWOFSA-N
Cross-matching ID
PubChem CID
446155
ChEBI ID
CHEBI:38565
CAS Number
93957-54-1
UNII
4L066368AS
DrugBank ID
DB01095
TTD ID
D08GHB
VARIDT ID
DR00124
INTEDE ID
DR0738
ACDINA ID
D00289
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [7]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [12]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [13]
Cytochrome P450 2C9 (CYP2C9)
Main DME 		DE5IED8 CP2C9_HUMAN Substrate [14]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [17]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Drug Response [6]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Drug Response [6]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Drug Response [6]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Drug Response [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Arteriosclerosis
ICD Disease Classification BD40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HMG-CoA reductase (HMGCR) DTT HMGCR 1.01E-05 0.65 1.53
P-glycoprotein 1 (ABCB1) DTP P-GP 3.29E-14 -7.08E-01 -1.99E+00
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTP OATP2B1 3.80E-01 -1.23E-02 -5.33E-02
Breast cancer resistance protein (ABCG2) DTP BCRP 2.28E-08 -3.66E-01 -8.07E-01
Organic anion transporting polypeptide 1B3 (SLCO1B3) DTP OATP1B3 1.65E-01 -6.07E-02 -3.77E-01
Organic anion transporting polypeptide 1B1 (SLCO1B1) DTP OATP1B1 3.27E-01 -5.78E-02 -3.84E-01
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 1.47E-02 -1.13E-01 -1.13E+00
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 3.65E-02 -8.90E-02 -5.58E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 5.05E-04 -1.51E-01 -8.87E-01
Cytochrome P450 1A1 (CYP1A1) DME CYP1A1 7.09E-03 -2.38E-01 -7.72E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 2.63E-03 -1.18E-01 -3.80E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 3.24E-05 -3.48E-01 -1.34E+00
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.666 4.5817 1.5715 29.4868
MEC1 CTRP2 3.7324 6.6133 3.3458 16.7844
JM1 CTRP2 4.3962 7.8412 3.5652 14.1091
EoL-1 CTRP2 0.1042 2.0001 0.1025 39.58
BL-70 CTRP2 0.2928 1.5863 0.2928 38.318
MOLM-16 CTRP2 0.8213 2.2845 0.8208 34.7986
MOLP-8 CTRP2 0.9005 4.5335 0.7594 34.721
DEL CTRP2 1.0563 2.1528 1.0562 33.2319
HD-MY-Z CTRP2 1.1631 4.5236 1.0422 32.9169
P12-Ichikawa CTRP2 1.1837 3.1827 1.175 32.4117
KMS-34 CTRP2 1.228 3.4385 1.2114 32.1426
SU-DHL-4 CTRP2 1.4013 3.1387 1.3968 30.9481
OPM-2 CTRP2 1.4265 4.1391 1.3693 30.9561
L-540 CTRP2 1.4462 3.1554 1.4419 30.6482
EM-2 CTRP2 1.514 2.729 1.5137 30.183
A4/Fukuda CTRP2 1.6565 3.2861 1.6526 29.2458
NALM-6 CTRP2 1.7185 3.4606 1.7118 28.8422
SUP-HD1 CTRP2 1.7195 3.4681 1.7126 28.8361
MV4-11 CTRP2 1.7322 3.6425 1.7201 28.7691
MOLT-16 CTRP2 1.8147 3.4958 1.8087 28.1989
GA-10 CTRP2 1.8549 3.051 1.8544 27.9125
MOLM-6 CTRP2 1.918 4.1738 1.8818 27.6122
NCI-H929 CTRP2 1.9386 3.4812 1.9346 27.3667
ST486 CTRP2 2.0574 4.1204 2.0309 26.6511
KE-37 CTRP2 2.1071 5.489 1.8854 26.9883
SET-2 CTRP2 2.1655 4.74 2.083 26.1209
Jurkat CTRP2 2.2211 4.8389 2.1286 25.7848
OCI-AML-3 CTRP2 2.2802 3.3007 2.28 25.0783
MOLM-13 CTRP2 2.3576 4.4226 2.3211 24.6849
SIG-M5 CTRP2 2.3768 3.9108 2.3695 24.4586
KE-97 CTRP2 2.3875 5.826 2.1109 25.3173
HuT 78 CTRP2 2.4023 5.4529 2.2141 24.9097
KMS-27 CTRP2 2.4675 4.7558 2.4025 24.0495
RCH-ACV CTRP2 2.474 5.8827 2.1909 24.7661
PF-382 CTRP2 2.4778 5.0046 2.3787 24.0981
HEL 92.1.7 CTRP2 2.5237 4.2845 2.5041 23.5211
SUP-T11 CTRP2 2.536 4.2176 2.5205 23.4253
SU-DHL-1 CTRP2 2.6007 3.201 2.6007 22.9425
F-36P CTRP2 2.647 4.0101 2.6418 22.6515
Daudi CTRP2 2.6653 4.5851 2.6295 22.6327
NU-DUL-1 CTRP2 2.6799 5.2476 2.5555 22.8397
JVM-2 CTRP2 2.732 5.3235 2.5977 22.5273
RS4;11 CTRP2 2.7706 6.3163 2.3938 23.1312
LP-1 CTRP2 2.8334 7.5377 2.0433 24.2079
KMS-18 CTRP2 2.8482 5.7781 2.6252 22.066
SU-DHL-8 CTRP2 2.8935 4.4366 2.8779 21.044
OCI-AML-5 CTRP2 2.9271 4.1088 2.9239 20.7786
MC116 CTRP2 2.9416 3.9895 2.9401 20.6762
Mino CTRP2 2.9462 4.2975 2.9383 20.6668
KMS-28BM CTRP2 2.9515 7.9844 1.9949 24.0386
SU-DHL-10 CTRP2 2.9775 4.1527 2.9741 20.4433
RPMI-8402 CTRP2 2.9803 4.4111 2.9686 20.4528
HEL CTRP2 3.0149 5.1976 2.925 20.4891
Mono-Mac-1 CTRP2 3.0852 7.5418 2.3107 22.5039
RPMI-6666 CTRP2 3.0939 4.1603 3.0917 19.6637
OCI-Ly3 CTRP2 3.1316 18.8602 -2.9278 35.6634
Pfeiffer CTRP2 3.228 4.8021 3.2005 18.8558
HL-60 CTRP2 3.2287 5.8765 3.0157 19.499
KM-H2 CTRP2 3.2484 5.1041 3.1889 18.8291
RL CTRP2 3.2729 6.2203 2.97 19.5289
Ku812 CTRP2 3.2877 5.6498 3.1338 18.8962
JJN-3 CTRP2 3.381 5.8956 3.177 18.4536
KCL-22 CTRP2 3.3974 5.4919 3.2856 18.018
Ki-JK CTRP2 3.4435 4.8783 3.4196 17.4079
EB1 CTRP2 3.4681 7.6695 2.6676 20.0882
KMS-12-BM CTRP2 3.493 7.2088 2.8735 19.2424
ALL-SIL CTRP2 3.4984 5.6052 3.3723 17.3954
KMS-20 CTRP2 3.5552 5.7448 3.4034 17.1081
Hs 611.T CTRP2 3.6029 7.0997 3.0322 18.3322
HPB-ALL CTRP2 3.6353 6.6925 3.2135 17.5599
HT CTRP2 3.6381 4.878 3.6224 16.0837
MM1.S CTRP2 3.7751 5.7759 3.6357 15.6006
EHEB CTRP2 3.7774 6.5037 3.4312 16.3362
Peer CTRP2 3.8414 5.8101 3.6999 15.1668
K-562 CTRP2 3.8922 6.2482 3.637 15.2389
NU-DHL-1 CTRP2 3.9841 7.6561 3.2166 16.5689
Kasumi-1 CTRP2 3.9983 6.1092 3.7934 14.3503
Ci-1 CTRP2 4.0249 8.4532 2.9152 17.6319
NCO2 CTRP2 4.0404 7.0359 3.5246 15.2298
AMO1 CTRP2 4.0553 5.3196 4.0201 13.3707
KMS-21-BM CTRP2 4.0912 5.6263 4.0107 13.2883
TALL-1 [Human adult T-ALL] CTRP2 4.1024 10.9174 1.8468 21.4848
Karpas-422 CTRP2 4.1473 6.5884 3.8035 13.8722
P31/FUJ CTRP2 4.1608 6.0213 3.995 13.1282
P3HR-1 CTRP2 4.1809 6.8235 3.7551 13.958
JVM-3 CTRP2 4.217 6.8933 3.7676 13.8085
KMS-26 CTRP2 4.2202 5.372 4.1888 12.2593
CMK CTRP2 4.299 5.617 4.2369 11.8402
Mono-Mac-6 CTRP2 4.3185 9.412 2.7704 17.4502
OCI-M1 CTRP2 4.3246 5.9794 4.1849 11.9445
JeKo-1 CTRP2 4.3247 8.0483 3.4008 14.9443
LAMA-84 CTRP2 4.3337 6.2108 4.1295 12.1176
Ri-1 CTRP2 4.4135 7.7145 3.6382 13.7761
WSU-DLCL2 CTRP2 4.4393 4.9789 4.4386 10.6956
OCI-Ly19 CTRP2 4.45 11.9171 1.6925 21.1889
SKM-1 CTRP2 4.4887 6.111 4.328 10.9288
MHH-CALL-4 CTRP2 4.5209 7.7597 3.7287 13.1378
KMS-11 CTRP2 4.5509 5.9128 4.4485 10.3052
MOLT-13 CTRP2 4.6015 6.7762 4.2232 10.9927
JURL-MK1 CTRP2 4.6176 6.5825 4.3132 10.6055
AML-193 CTRP2 4.6579 6.87 4.2466 10.7462
MOTN-1 CTRP2 4.6858 8.9132 3.3646 14.1825
CML-T1 CTRP2 4.7183 6.8786 4.3072 10.3461
HDLM-2 CTRP2 4.7222 9.5674 3.0881 15.2084
Granta-519 CTRP2 4.7416 8.5943 3.5694 13.2202
SR CTRP2 4.9563 5.8966 4.8937 7.4653
SUP-B15 CTRP2 5.0214 8.1672 4.0442 10.6149
SU-DHL-6 CTRP2 5.0279 7.1811 4.5028 8.7525
L-428 CTRP2 5.0759 8.7285 3.8292 11.364
BV-173 CTRP2 5.1422 6.6323 4.8544 7.0701
DB CTRP2 5.1506 8.7122 3.9081 10.8662
OCI-AML-2 CTRP2 5.1599 7.2183 4.6208 7.9433
NB4 CTRP2 5.1681 6.4424 4.9561 6.6083
RPMI-8226 CTRP2 5.183 6.4568 4.9666 6.5264
PL21 CTRP2 5.1947 6.2748 5.0453 6.1961
Karpas-299 CTRP2 5.2414 6.0439 5.1682 5.6055
KHM-1B CTRP2 5.2778 7.3275 4.6892 7.372
SEM CTRP2 5.2845 6.887 4.8951 6.5306
THP-1 CTRP2 5.3038 9.7046 3.5656 11.932
M-07e CTRP2 5.329 7.2648 4.7692 6.9223
SUP-T1 CTRP2 5.3357 6.4242 5.142 5.4291
GDM-1 CTRP2 5.3516 6.7596 5.0198 5.8622
SK-MM-2 CTRP2 5.3529 7.5102 4.6778 7.2347
U-937 CTRP2 5.4536 6.2253 5.3426 4.3348
Reh CTRP2 5.4866 6.3736 5.3223 4.3189
Kasumi-2 CTRP2 5.4942 6.8249 5.1361 5.032
TF-1 CTRP2 5.509 6.5538 5.2712 4.4571
ME1 CTRP2 5.5175 7.1923 4.9884 5.5725
KO52 CTRP2 5.5378 8.2978 4.4719 7.6572
MJ CTRP2 5.6259 8.4098 4.4971 7.3594
L-363 CTRP2 5.6375 6.0782 5.5907 2.876
Raji CTRP2 5.6575 6.2929 5.5355 3.0262
KYO-1 CTRP2 5.7733 10.3384 3.6675 10.5153
MOLP-2 CTRP2 5.9364 7.6436 5.1531 3.9603
MHH-CALL-3 CTRP2 6.0128 8.9372 4.5716 6.2518
DND-41 CTRP2 6.3155 7.7815 5.3902 2.2689
U266B1 CTRP2 6.3574 10.938 3.8533 8.6146
REC-1 CTRP2 6.647 10.8801 4.1086 7.0416
Karpas-620 CTRP2 8.1104 9.3842 5.6344 0.1079
EJM CTRP2 8.1287 22.2038 -0.3708 20.339
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 2.0505 3.3467 2.0491 26.6127
TE15 CTRP2 2.0591 6.0909 1.6823 27.8399
TE-6 CTRP2 1.4897 3.6834 1.4691 30.4128
TE-11 CTRP2 2.1536 4.9607 2.0375 26.3152
KYSE-180 CTRP2 2.7072 5.7579 2.4765 23.0311
KYSE-30 CTRP2 2.7737 3.2758 2.7737 21.7896
TE-9 CTRP2 2.8056 3.8444 2.8046 21.5807
TE-4 CTRP2 3.1592 6.195 2.8533 20.2954
KYSE-520 CTRP2 3.6361 10.84 1.4307 24.1405
KYSE-140 CTRP2 3.7231 6.4435 3.3918 16.6418
KYSE-150 CTRP2 3.7906 5.5789 3.6944 15.3452
TE-5 CTRP2 3.7962 7.2379 3.1863 17.203
OE21 CTRP2 4.1722 7.9989 3.266 15.8738
TE-10 CTRP2 4.2765 8.4278 3.1822 15.9322
OE33 CTRP2 4.9061 23.1282 -3.4637 32.7124
KYSE-450 CTRP2 5.1446 8.9171 3.8033 11.3107
EC-GI-10 CTRP2 5.1879 14.1572 1.2538 21.0174
TE-14 CTRP2 5.2155 7.6982 4.4549 8.4746
KYSE-510 CTRP2 5.6152 6.9373 5.2041 4.4581
KYSE-410 CTRP2 5.6168 6.4326 5.4349 3.5283
KYSE-70 CTRP2 5.637 6.2443 5.5328 3.094
TE-1 CTRP2 5.8839 6.7402 5.5551 2.3889
COLO 680N CTRP2 6.9334 10.7744 4.3731 5.4825
OE19 CTRP2 7.2424 9.0142 5.399 1.0962
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 5.6494 10.402 3.5282 11.3477
KP-4 CTRP2 1.3373 4.256 1.2627 31.6076
MIA PaCa-2 CTRP2 1.7919 3.6023 1.7825 28.3624
PSN1 CTRP2 2.0946 4.1056 2.0705 26.3951
Panc 03.27 CTRP2 2.1696 4.5371 2.1121 26.0084
KP-3 CTRP2 2.279 7.7999 1.3508 28.2717
QGP-1 CTRP2 2.4141 15.9956 -2.2061 36.323
KP-2 CTRP2 2.7671 4.6497 2.7305 21.9571
SW1990 CTRP2 3.0021 8.9134 1.6621 25.0735
SU.86.86 CTRP2 3.2449 7.3883 2.5401 21.1972
BxPC-3 CTRP2 3.5911 5.8872 3.4083 16.9799
Panc 04.03 CTRP2 3.6044 8.6835 2.3833 20.7876
Panc 08.13 CTRP2 4.0145 6.5193 3.6834 14.7061
Panc 02.03 CTRP2 4.0926 7.3379 3.4611 15.3286
PK-45H CTRP2 4.3947 9.5455 2.7821 17.2159
SNU-213 CTRP2 4.7339 5.9498 4.6389 9.0607
SUIT-2 CTRP2 4.7879 6.5621 4.5036 9.4009
HuP-T4 CTRP2 5.5606 6.2156 5.4614 3.5808
PK-59 CTRP2 5.7698 6.5086 5.5568 2.6493
DAN-G CTRP2 5.7848 7.1717 5.252 3.868
CFPAC-1 CTRP2 5.7914 8.712 4.4943 7.0206
L3.3 CTRP2 5.8091 6.3011 5.6903 2.0151
YAPC CTRP2 5.8407 6.3962 5.6793 1.9789
HPAC CTRP2 5.8589 6.7307 5.5366 2.5216
HPAF-II CTRP2 5.8618 8.351 4.7356 5.8641
Hs 766T CTRP2 5.9236 12.2313 2.8497 13.5565
TCC-Pan2 CTRP2 6.0263 11.1805 3.4613 10.8665
PaTu 8902 CTRP2 6.1547 7.3848 5.4638 2.2358
PaTu 8988s CTRP2 6.2897 8.0768 5.2247 2.9999
PaTu 8988t CTRP2 6.2976 9.4456 4.5499 5.8099
Panc 05.04 CTRP2 6.367 8.5684 5.0401 3.6383
Panc 10.05 CTRP2 6.6628 10.179 4.4671 5.5271
AsPC-1 CTRP2 7.417 12.6953 3.7818 7.1481
SNU-410 CTRP2 7.6665 13.0236 3.7967 6.7204
Capan-2 CTRP2 8.0297 15.8005 2.7055 10.4426
HuP-T3 CTRP2 8.2576 20.407 0.6137 17.2949
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.1502 16.1458 1.8831 14.9429
Hs 944.T CTRP2 -0.0438 3.1107 -0.0846 40.6783
RPMI-7951 CTRP2 0.7015 1.3658 0.7015 35.5952
HMCB CTRP2 0.9365 1.9611 0.9365 34.0297
CJM [Human melanoma] CTRP2 1.4837 3.1267 1.4804 30.3949
SK-MEL-2 CTRP2 1.8927 3.3383 1.8903 27.6669
WM115 CTRP2 2.2876 4.8353 2.2002 25.3244
Hs 294T CTRP2 2.4601 3.8178 2.4564 23.8917
Hs 895.T CTRP2 2.5701 7.9409 1.6072 26.5229
A101D CTRP2 2.6395 3.3259 2.6395 22.6842
UACC-62 CTRP2 2.821 4.9841 2.7492 21.7181
MeWo CTRP2 2.8559 7.5729 2.0539 24.1039
K029AX CTRP2 2.9123 7.4133 2.1746 23.5027
IGR-39 CTRP2 2.9447 5.8366 2.716 21.4446
WM983B CTRP2 3.0518 9.1049 1.6308 25.0416
WM88 CTRP2 3.2888 5.75 3.1121 18.9699
IGR-1 CTRP2 3.5513 11.7778 0.9048 26.0857
LOX-IMVI CTRP2 3.7868 7.7685 2.9631 18.0827
COLO 792 CTRP2 3.8171 7.3322 3.1717 17.2003
A2058 CTRP2 4.0245 6.2641 3.7764 14.3333
Mel JuSo CTRP2 4.924 5.6831 4.8981 7.5522
A-375 CTRP2 5.0578 6.4605 4.8311 7.3947
MDA-MB-435S CTRP2 5.3115 6.1544 5.2121 5.2351
IGR-37 CTRP2 5.3789 8.78 4.0889 9.6
G-361 CTRP2 5.4258 13.0487 2.0143 17.811
SK-MEL-5 CTRP2 5.4775 5.9795 5.4422 3.8988
HT-144 CTRP2 5.5098 9.0296 4.0858 9.3249
WM793 CTRP2 5.6027 6.829 5.2426 4.3323
SK-MEL-3 CTRP2 5.699 8.5663 4.4851 7.2526
IPC-298 CTRP2 5.7008 6.1276 5.6438 2.4931
Hs 936.T CTRP2 5.8882 6.5208 5.6661 1.9196
SK-MEL-30 CTRP2 5.9631 6.6451 5.6738 1.7222
Hs 852.T CTRP2 5.9858 7.2729 5.3806 2.9053
Hs 940.T CTRP2 6.1438 7.5543 5.3706 2.6463
SK-MEL-31 CTRP2 6.1643 7.2135 5.5565 1.8309
UACC-257 CTRP2 6.3279 10.9565 3.8204 8.8053
SK-MEL-28 CTRP2 6.4393 7.5301 5.5993 1.232
COLO 800 CTRP2 6.6859 13.8166 2.6791 12.7817
RVH-421 CTRP2 6.6879 10.6273 4.2646 6.3253
Hs 934.T CTRP2 6.8509 11.0626 4.1715 6.4426
WM266-4 CTRP2 6.8518 12.74 3.3434 9.8386
Mel Ho CTRP2 7.1462 14.673 2.6104 12.2366
SK-MEL-1 CTRP2 7.2453 12.6239 3.6939 7.7678
Hs 688(A).T CTRP2 7.6207 15.2611 2.6746 11.2013
WT2-iPS CTRP2 8.1872 9.4402 5.6425 0.0877
COLO 829 CTRP2 8.2887 18.1244 1.7573 13.4976
Hs 839.T CTRP2 9.4216 21.6611 0.84 14.8105
WM1799 CTRP2 11.3366 23.059 1.4389 10.4293
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 6.3609 13.3319 2.6609 13.4547
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH CTRP2 1.1439 3.6437 1.1137 32.7482
IMR-32 CTRP2 2.2274 54.3147 -21.341 46.1503
MHH-NB-11 CTRP2 4.2519 5.5086 4.2042 12.1042
SK-N-FI CTRP2 4.9593 6.3583 4.7618 7.9378
SiMa CTRP2 5.184 6.4852 4.9568 6.5609
KP-N-SI9s CTRP2 5.2597 9.5167 3.6176 11.8151
NB1 CTRP2 5.3343 5.9221 5.2991 4.8519
Kelly CTRP2 5.4743 7.6422 4.7319 6.7255
SK-N-BE(2) CTRP2 5.614 6.6207 5.3493 3.8746
CHP-126 CTRP2 6.3658 10.9038 3.8771 8.5001
NH-6 CTRP2 6.4242 11.0308 3.8602 8.4647
KP-N-YN CTRP2 7.5482 9.4174 5.3851 0.8933
SK-N-DZ CTRP2 7.8671 9.1891 5.6129 0.1893
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-28 CTRP2 -0.0444 1.5638 -0.0448 40.5657
SNU-869 CTRP2 1.6487 12.3092 -1.2255 36.82
SNU-1079 CTRP2 4.1954 5.6088 4.1266 12.5537
SNU-478 CTRP2 4.4392 7.3875 3.8047 13.0547
SNU-308 CTRP2 5.2308 9.157 3.7671 11.2633
SNU-1196 CTRP2 6.3701 9.3743 4.6425 5.2931
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MG-63 CTRP2 0.5715 2.6346 0.566 36.4792
A-673 CTRP2 1.6706 2.9561 1.6699 29.1411
Hs 888.T CTRP2 2.1575 7.3997 1.3681 28.5919
HOS CTRP2 2.4523 3.4833 2.4519 23.9324
TC71 CTRP2 2.6157 3.2762 2.6157 22.8423
SJSA-1 CTRP2 2.749 5.7772 2.5173 22.7568
MHH-ES-1 CTRP2 2.7881 3.9632 2.7856 21.7022
SaOS-2 CTRP2 2.792 3.7969 2.7912 21.6705
SK-ES-1 CTRP2 3.0532 4.3731 3.045 19.9549
CADO-ES1 CTRP2 3.5401 6.2046 3.266 17.6483
SK-N-MC CTRP2 3.6447 5.032 3.6171 16.08
SW1353 CTRP2 4.4921 6.6264 4.1621 11.5336
CAL-78 CTRP2 5.2766 6.3382 5.1112 5.7128
G-292 clone A141B1 CTRP2 5.6486 7.544 4.9437 5.4519
Hs 822.T CTRP2 6.6593 10.3781 4.3663 5.9512
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 CTRP2 2.7887 4.7667 2.7416 21.8487
BT-549 CTRP2 2.9993 6.445 2.6038 21.6822
HMC-1-8 CTRP2 3.4271 5.2132 3.3646 17.6488
HCC1419 CTRP2 3.553 8.7 2.3232 21.1517
Hs 578T CTRP2 3.7594 7.0663 3.2125 17.2073
MDA-MB-231 CTRP2 3.8577 6.6234 3.4781 15.9273
MDA-MB-468 CTRP2 4.2332 6.1517 4.0375 12.7547
CAL-148 CTRP2 4.2597 5.8442 4.1475 12.2782
HCC1806 CTRP2 4.637 5.79 4.5697 9.6076
EFM-192A CTRP2 4.6551 9.6158 3.0006 15.7189
HCC1954 CTRP2 4.9195 6.0157 4.8245 7.8259
HCC1395 CTRP2 4.9625 8.8227 3.6755 12.2585
CAL-85-1 CTRP2 5.3067 10.7991 3.0274 14.1257
MCF-7 CTRP2 5.6837 8.1452 4.6801 6.471
HCC1143 CTRP2 5.7028 7.9318 4.8027 5.9182
JIMT-1 CTRP2 5.7988 7.3071 5.1983 4.0605
AU565 CTRP2 5.9392 11.279 3.3389 11.5415
BT-20 CTRP2 6.1451 14.0272 2.1366 15.881
Hs 578Bst CTRP2 6.1701 12.8943 2.7236 13.5733
HCC2218 CTRP2 6.2629 10.1609 4.1653 7.4847
KPL-1 CTRP2 6.3596 10.8876 3.8802 8.4984
ZR-75-1 CTRP2 6.3867 8.0095 5.3305 2.4012
HCC202 CTRP2 6.5489 10.6677 4.1386 7.0854
HCC1500 CTRP2 6.5666 12.1976 3.3914 10.1438
HDQ-P1 CTRP2 6.6428 9.287 4.8907 3.8092
HCC38 CTRP2 6.8964 11.9003 3.7926 7.9281
ZR-75-30 CTRP2 7.1326 13.5791 3.141 10.177
MDA-MB-453 CTRP2 7.2241 10.8735 4.5281 4.4232
BT-474 CTRP2 7.3434 9.1631 5.3883 1.0442
HCC1937 CTRP2 7.3441 12.8711 3.6443 7.8141
MDA-MB-361 CTRP2 7.4872 9.9041 5.143 1.7478
T-47D CTRP2 7.6109 12.3808 4.0675 5.7213
CAMA-1 CTRP2 7.7279 14.1691 3.2852 8.6582
HCC1428 CTRP2 8.9002 15.4817 3.4403 6.4546
BT 271 CTRP2 3.1582 34.5922 -10.7008 42.1722
BT 172 CTRP2 4.5423 12.3474 1.5677 21.4101
BT 239 CTRP2 4.6504 8.6871 3.4362 13.9805
BT 416 CTRP2 4.7699 7.2591 4.203 10.613
BT 145 CTRP2 5.2327 8.1204 4.2711 9.1837
BT 245 CTRP2 5.353 9.4505 3.7357 11.1211
BT 231 CTRP2 5.402 9.201 3.9033 10.3189
BT 428 CTRP2 5.6709 8.524 4.4811 7.3292
BT 482 CTRP2 5.7941 6.8325 5.4263 3.1255
BT 159 CTRP2 6.1285 8.2227 5.0246 4.1271
BT 216 CTRP2 6.3899 8.3827 5.1492 3.1463
BT147 CTRP2 6.4364 9.7545 4.505 5.752
BT 228 CTRP2 6.4814 8.7901 5.0165 3.5469
BT 286 CTRP2 6.5314 13.2376 2.8451 12.4104
BT164 CTRP2 6.8027 10.412 4.4558 5.3477
BT 139 CTRP2 6.9042 8.0789 5.6228 0.6501
BT 498 CTRP2 6.9872 10.3025 4.6407 4.3097
BT 359 CTRP2 7.0351 14.5986 2.5623 12.6138
BT 320 CTRP2 7.1918 10.0437 4.901 2.9903
BT 444 CTRP2 7.4026 11.0684 4.5541 4.0758
BT 187 CTRP2 7.5747 15.6845 2.4326 12.1945
BT 422 CTRP2 7.5955 14.3634 3.0961 9.6059
BT 248 CTRP2 8.2295 9.6757 5.5764 0.1557
BT 328 CTRP2 8.3113 13.8204 3.8442 5.6617
BT 340 CTRP2 8.4563 17.0195 2.4137 10.8912
BT 224 CTRP2 8.7461 18.0173 2.1326 11.4826
BT 504 CTRP2 8.8603 23.8553 -0.6371 19.8758
BT 112 CTRP2 8.907 18.0352 2.2344 10.8877
BT 232 CTRP2 8.9763 21.2456 0.727 15.82
BT 330 CTRP2 9.501 24.4872 -0.4791 18.4915
BT 131 CTRP2 9.7695 24.1023 -0.1 17.0705
BT 179 CTRP2 11.5611 21.5812 2.2494 7.5956
BT 333 CTRP2 12.5649 29.1706 -0.6409 14.8915
BT 440 CTRP2 12.8765 27.7545 0.217 12.2656
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 2.7887 4.452 2.7684 21.7581
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1783 CTRP2 -0.1583 20.4202 -6.7958 46.7028
A-172 CTRP2 -0.054 3.4647 -0.1236 40.822
SNU-466 CTRP2 0.551 3.4312 0.5119 36.7229
SF268 CTRP2 0.7135 4.6021 0.5474 36.0318
SF126 CTRP2 0.7461 2.5884 0.7431 35.3079
Daoy CTRP2 0.9258 2.5485 0.9244 34.1055
GB-1 CTRP2 1.0794 4.7064 0.9239 33.5829
SF295 CTRP2 1.589 4.2375 1.5306 29.8782
U-251MG CTRP2 1.7319 4.9162 1.5911 29.2046
DK-MG CTRP2 1.7711 4.1347 1.7313 28.603
YH-13 CTRP2 1.8141 3.3866 1.8102 28.1957
KNS-60 CTRP2 1.9061 3.6804 1.8966 27.6017
D283 Med CTRP2 1.9067 4.0822 1.8768 27.6662
U-118MG CTRP2 2.2694 6.0601 1.9203 26.3543
M059K CTRP2 2.2804 4.532 2.2296 25.2473
LN-18 CTRP2 2.5331 4.1356 2.5214 23.4318
LN-229 CTRP2 2.6423 4.4971 2.6128 22.7644
SNU-626 CTRP2 2.6901 5.2255 2.5704 22.7553
T98G CTRP2 2.7716 5.3685 2.6319 22.2828
ONS-76 CTRP2 2.7824 3.8882 2.7809 21.7371
Becker CTRP2 2.8717 6.1437 2.5544 22.2467
8-MG-BA CTRP2 3.0785 5.5926 2.9189 20.309
SNU-1105 CTRP2 3.1463 4.2217 3.1437 19.3162
KG-1-C CTRP2 3.3793 8.1757 2.3671 21.4635
CAS-1 CTRP2 3.4874 8.205 2.4677 20.7882
KNS-81 CTRP2 3.4898 9.8932 1.7248 23.5066
Hs 683 CTRP2 3.512 6.0487 3.2795 17.6845
SF539 CTRP2 3.7735 7.3351 3.1241 17.5033
U-87MG ATCC CTRP2 3.9414 6.6594 3.5562 15.3927
SNU-489 CTRP2 4.1866 6.4754 3.8848 13.4545
SNU-738 CTRP2 4.4377 6.4259 4.1737 11.6471
CCF-STTG1 CTRP2 4.9656 8.4618 3.8506 11.5373
SNB-75 CTRP2 5.2786 10.2118 3.2926 13.1089
KALS-1 CTRP2 5.3526 6.232 5.231 5.0443
GMS-10 CTRP2 5.5634 11.2271 3.0421 13.5188
GaMG CTRP2 5.6529 6.2111 5.5623 2.9367
42-MG-BA CTRP2 5.717 7.0795 5.2338 4.0967
SW1088 CTRP2 5.7325 12.835 2.3858 15.7642
DBTRG-05MG CTRP2 5.7509 7.2512 5.1818 4.2351
TM-31 CTRP2 5.9788 11.2275 3.398 11.2205
SNU-201 CTRP2 6.3148 9.8282 4.3729 6.5204
GOS-3 CTRP2 6.7868 14.3549 2.4904 13.3302
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP2 -1.9934 4.4525 -2.3498 53.0366
JHUEM-2 CTRP2 1.0426 3.4279 1.0211 33.3941
ESS-1 CTRP2 1.1986 3.2715 1.1876 32.32
JHUEM-3 CTRP2 1.349 10.1792 -0.5941 36.5482
HEC-1-A CTRP2 2.2955 5.1711 2.1542 25.4574
HEC-6 CTRP2 2.401 4.262 2.3784 24.3484
KLE CTRP2 2.8146 8.7105 1.553 25.9889
RL95-2 CTRP2 2.8562 3.9895 2.8541 21.2473
HEC-251 CTRP2 3.0123 5.901 2.7735 21.0309
AN3-CA CTRP2 3.0637 5.4467 2.933 20.3062
MFE-319 CTRP2 3.2752 5.0437 3.2252 18.6178
HEC-50B CTRP2 3.3762 8.7087 2.1372 22.3245
JHUEM-7 CTRP2 3.5235 5.6616 3.3875 17.2633
MFE-296 CTRP2 3.5811 5.4206 3.4972 16.6974
HEC-1-B CTRP2 4.2392 6.3223 3.992 12.9036
JHUEM-1 CTRP2 4.5364 7.6016 3.8139 12.7607
HEC-59 CTRP2 4.6459 6.2976 4.4422 10.0415
HEC-151 CTRP2 5.7542 6.379 5.5999 2.516
EFE-184 CTRP2 6.1414 7.0576 5.6163 1.6208
HEC-108 CTRP2 6.1603 9.016 4.654 5.6242
EN CTRP2 7.6084 14.3542 3.1098 9.532
Ishikawa (Heraklio) 02 ER- CTRP2 3.2929 4.1357 3.2924 18.3325
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR10TKB CTRP2 1.2524 3.4278 1.2369 31.9767
UO-31 CTRP2 1.3666 4.7718 1.222 31.644
ACHN CTRP2 1.4121 3.6395 1.3913 30.9301
786-O CTRP2 2.4423 4.6822 2.3844 24.193
Caki-2 CTRP2 2.7926 4.5506 2.7656 21.7546
Caki-1 CTRP2 3.253 6.2214 2.948 19.6688
KMRC-1 CTRP2 3.531 6.4738 3.1732 18.0151
TUHR14TKB CTRP2 4.2262 13.9611 0.4847 25.667
TUHR4TKB CTRP2 4.501 6.7717 4.1175 11.6776
OS-RC-2 CTRP2 4.7426 9.5149 3.1329 14.9801
769-P CTRP2 5.3929 6.4733 5.1833 5.1126
VMRC-RCW CTRP2 5.4111 6.267 5.2819 4.6851
SNU-1272 CTRP2 5.5646 9.8431 3.7317 10.6812
KMRC-3 CTRP2 5.8714 8.6774 4.5811 6.493
KMRC-20 CTRP2 5.9998 7.7198 5.1693 3.7653
VMRC-RCZ CTRP2 6.8167 11.4734 3.9436 7.439
RCC10RGB CTRP2 7.1864 8.8924 5.4218 1.0698
KMRC-2 CTRP2 10.0994 22.7785 0.768 14.0783
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP2d CTRP2 -0.8601 7.9616 -2.0894 47.0704
COLO 678 CTRP2 1.4605 5.2575 1.2326 31.2952
HCT 15 CTRP2 2.1283 5.2524 1.9579 26.6705
NCI-H716 CTRP2 2.2864 4.0971 2.2693 25.0938
NCI-H747 CTRP2 2.5093 4.5515 2.4688 23.6875
T84 CTRP2 2.7521 4.0256 2.7482 21.9467
HT115 CTRP2 2.94 3.9648 2.4999 3.1889
LS180 CTRP2 3.0014 5.0668 2.9304 20.5138
SW1417 CTRP2 3.2206 9.2908 1.7229 24.2474
CW-2 CTRP2 3.425 7.0427 2.8622 19.4791
SK-CO-1 CTRP2 3.654 5.2814 3.5974 16.1174
SW48 CTRP2 3.9385 6.2673 3.6816 14.9372
HCT 116 CTRP2 4.105 5.0949 4.093 12.9606
DLD-1 CTRP2 4.3908 6.3888 4.1352 11.9276
HCC-56 CTRP2 4.5706 6.2654 4.3706 10.5278
COLO205 CTRP2 5.0025 6.1894 4.8647 7.4296
SNU-C2A CTRP2 5.0054 6.7032 4.6812 8.1142
CCK-81 CTRP2 5.1252 9.1012 3.6956 11.7979
LoVo CTRP2 5.3539 7.3675 4.7459 6.9553
CL-11 CTRP2 5.4037 6.4045 5.2221 4.9334
MDST8 CTRP2 5.4077 6.0513 5.3477 4.4517
SW620 CTRP2 5.4742 6.4108 5.2943 4.4605
LS1034 CTRP2 5.4804 6.8832 5.0957 5.2288
HCT 8 CTRP2 5.5511 7.9885 4.6358 6.9472
OUMS-23 CTRP2 5.5749 6.4704 5.3753 3.8735
HT-55 CTRP2 5.6055 6.064 5.5599 3.0844
LS513 CTRP2 5.6337 6.3473 5.4883 3.2745
LS411N CTRP2 5.6875 7.0522 5.2191 4.2257
COLO201 CTRP2 5.7458 6.4121 5.5766 2.6305
SNU-C5 CTRP2 5.7601 8.3113 4.6661 6.3665
SNU-1033 CTRP2 5.7902 7.2404 5.2233 3.9755
COLO 320 CTRP2 5.829 8.5511 4.6073 6.4694
NCI-H508 CTRP2 5.831 6.4947 5.6236 2.229
SW1116 CTRP2 5.8341 7.3204 5.2237 4.4804
LS123 CTRP2 5.8529 6.7194 5.5365 2.5355
KM12 CTRP2 5.8532 6.6482 5.5714 2.3905
HT-29 CTRP2 5.8602 6.6349 5.5844 2.3209
SNU-407 CTRP2 6.0015 7.2636 5.3987 2.7981
RKO CTRP2 6.0035 7.2278 5.4183 2.7117
SW948 CTRP2 6.1056 7.2505 5.4916 2.2082
RCM-1 [Human ESC] CTRP2 6.1766 9.1731 4.5888 5.8678
SNU-C1 CTRP2 6.5122 11.6029 3.6447 9.1999
SNU-C4 CTRP2 7.4069 8.5826 5.653 0.2689
C2BBe1 CTRP2 7.447 14.88 2.734 11.255
SNU-503 CTRP2 7.5622 14.3949 3.0566 9.8135
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-886 CTRP2 -2.234 0.3769 -2.2362 55.1319
JHH-2 CTRP2 -0.5949 4.8963 -0.9232 44.7869
SNU-423 CTRP2 0.327 3.7003 0.2546 38.3103
SNU-761 CTRP2 0.9795 3.3717 0.959 33.8109
SNU-449 CTRP2 1.098 3.7799 1.0563 33.0916
SNU-387 CTRP2 1.4793 6.9655 0.7834 32.6406
SNU-878 CTRP2 1.7664 3.4682 1.7602 28.5212
PLC/PRF/5 CTRP2 1.7858 11.5901 -0.7622 35.4967
SNU-182 CTRP2 1.8399 5.5847 1.5728 28.9154
JHH-5 CTRP2 1.9494 3.6768 1.9408 27.3101
JHH-4 CTRP2 2.1116 2.9764 2.1115 26.2012
HLF CTRP2 2.1941 5.301 2.0196 26.247
SNU-398 CTRP2 2.5671 6.7663 2.0303 25.049
Li-7 CTRP2 2.7822 4.9591 2.7112 21.974
SK-HEP-1 CTRP2 3.725 6.5324 3.3649 16.7356
SNU-475 CTRP2 3.7923 10.073 1.9431 21.9247
JHH-1 CTRP2 4.3922 5.6054 4.3394 11.1871
Hep 3B2.1-7 CTRP2 5.0202 6.4705 4.787 7.6687
HuH-6 CTRP2 5.2551 6.5358 5.0125 6.1501
Hep-G2 CTRP2 6.0225 7.1842 5.4562 2.5151
HuH-1 CTRP2 6.2599 8.6074 4.9378 4.2519
JHH-6 CTRP2 7.241 8.0143 5.7946 0.077
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 138 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC4006 CTRP2 -3.7659 -0.015 -3.7767 64.8654
PC-14 CTRP2 -1.0002 1.7695 -1.0096 46.9484
HCC44 CTRP2 -0.1551 1.8307 -0.157 41.3078
NCI-H838 CTRP2 0.2078 1.4422 0.2077 38.8846
T3M-10 CTRP2 0.2124 8.6613 -1.1867 41.683
NCI-H661 CTRP2 0.2972 2.6512 0.2872 38.3206
NCI-H446 CTRP2 0.3176 3.0577 0.2926 38.2313
HCC15 CTRP2 0.3731 1.8951 0.3727 37.7842
NCI-H1915 CTRP2 0.6136 3.785 0.5481 36.3886
Lu-99 CTRP2 0.6364 2.1602 0.6358 36.031
Lu-65 CTRP2 0.7562 4.1611 0.6573 35.5458
HCC827 CTRP2 0.7811 3.807 0.7221 35.2556
NCI-H1975 CTRP2 0.9365 2.7009 0.9337 34.0389
HCC1195 CTRP2 1.2886 3.835 1.2509 31.8093
HOP-92 CTRP2 1.378 6.1303 0.9281 32.5445
RERF-LC-MS CTRP2 1.4878 3.2765 1.4818 30.3768
HOP-62 CTRP2 1.5463 3.5209 1.5344 30.0067
NCI-H810 CTRP2 1.5541 6.3277 1.0638 31.5262
NCI-H23 CTRP2 1.6378 5.2473 1.4272 30.064
HCC2279 CTRP2 1.7721 3.8488 1.7518 28.5305
NCI-H1734 CTRP2 1.7931 3.7296 1.7791 28.3695
NCI-H647 CTRP2 1.977 6.9344 1.3341 29.2739
DMS 273 CTRP2 1.9925 4.1538 1.9611 27.0996
SW1271 CTRP2 1.9993 3.6249 1.9931 26.9697
NCI-H2085 CTRP2 2.0522 8.4391 0.861 30.5357
NCI-H292 CTRP2 2.0835 3.7661 2.0749 26.4169
LOU-NH91 CTRP2 2.1299 4.6185 2.0606 26.3127
SBC-5 CTRP2 2.2437 8.2377 1.1438 29.0553
NCI-H1155 CTRP2 2.3076 4.918 2.2095 25.2277
SK-MES-1 CTRP2 2.3362 5.0035 2.2268 25.0767
NCI-H2030 CTRP2 2.3432 5.5609 2.1262 25.4034
NCI-H1105 CTRP2 2.3618 7.7788 1.4473 27.6961
COR-L105 CTRP2 2.4247 6.6804 1.9037 25.9308
NCI-H226 CTRP2 2.4748 5.6176 2.2565 24.5329
NCI-H1563 CTRP2 2.4825 7.6683 1.6183 26.7482
HCC1438 CTRP2 2.562 3.0054 2.562 23.2002
NCI-H2228 CTRP2 2.5648 5.0727 2.4613 23.5338
RERF-LC-A1 CTRP2 2.8243 5.8049 2.5926 22.2562
NCI-H1838 CTRP2 2.8337 5.2991 2.7122 21.8054
NCI-H1703 CTRP2 2.8369 8.8008 1.5384 25.9743
HCC78 CTRP2 2.9086 3.8863 2.9079 20.8935
HCC2108 CTRP2 2.9395 5.8632 2.7037 21.5044
NCI-H1299 CTRP2 3.0129 4.726 2.9816 20.3016
Calu-3 CTRP2 3.0239 5.6044 2.857 20.6985
NCI-H358 CTRP2 3.0385 6.4754 2.6369 21.4442
NCI-H2081 CTRP2 3.1 9.6797 1.4273 25.6041
NCI-H1650 CTRP2 3.2092 7.8112 2.3369 22.0527
NCI-H211 CTRP2 3.2969 8.0878 2.3172 21.8789
NCI-H1339 CTRP2 3.3281 7.0115 2.7693 20.105
NCI-H1581 CTRP2 3.5155 6.5336 3.1369 18.1947
DV-90 CTRP2 3.5866 6.9701 3.0625 18.2647
NCI-H196 CTRP2 3.6557 6.2746 3.3712 16.9177
NCI-H1568 CTRP2 3.7074 7.7307 2.8953 18.5599
NCI-H1341 CTRP2 3.7713 6.4335 3.4474 16.2943
LCLC-103H CTRP2 3.8564 5.4266 3.7925 14.7944
NCI-H2291 CTRP2 3.9247 9.2664 2.4471 19.7
HARA [Human squamous cell lung carcinoma] CTRP2 4.0473 9.0999 2.6462 18.619
HCC366 CTRP2 4.0992 6.8501 3.6576 14.559
CAL-12T CTRP2 4.1196 9.0977 2.7194 18.1499
NCI-H522 CTRP2 4.4098 14.4547 0.4099 25.4491
COR-L88 CTRP2 4.4735 8.9932 3.1189 15.6875
NCI-H1395 CTRP2 4.5189 14.3961 0.5378 24.814
DMS 53 CTRP2 4.6029 24.4068 -4.3641 34.5801
EKVX CTRP2 4.6192 9.5237 3.0102 15.7662
NCI-H1355 CTRP2 4.658 10.1677 2.7379 16.755
HCC1171 CTRP2 4.6721 8.0455 3.7542 12.649
NCI-H2110 CTRP2 4.7196 7.6687 3.972 11.6581
MOR/CPR CTRP2 4.7476 5.6597 4.7126 8.7583
NCI-H650 CTRP2 4.7872 8.5793 3.6211 12.8998
NCI-H2009 CTRP2 4.8873 7.7349 4.1119 10.6725
RERF-LC-Ad1 CTRP2 4.9478 7.39 4.3285 9.6522
NCI-H2087 CTRP2 4.9712 6.4954 4.7252 8.0416
NCI-H1793 CTRP2 5.0026 9.68 3.2991 13.701
NCI-H2405 CTRP2 5.028 7.5239 4.3494 9.3645
NCI-H526 CTRP2 5.0294 6.5668 4.7604 7.7436
Calu-1 CTRP2 5.1393 12.1001 2.2327 17.6145
NCI-H520 CTRP2 5.1852 8.4108 4.0863 10.0536
HCC95 CTRP2 5.2534 7.1206 4.7593 7.1514
COLO 668 CTRP2 5.2628 9.5171 3.6203 11.797
KNS-62 CTRP2 5.3303 8.0903 4.3788 8.513
LK2 CTRP2 5.3802 6.0107 5.3285 4.6051
LXF 289 CTRP2 5.3958 10.0466 3.4801 12.0836
Sq-1 CTRP2 5.4197 6.347 5.2614 4.7385
NCI-H2122 CTRP2 5.4247 6.0779 5.3586 4.3608
Calu-6 CTRP2 5.4423 6.9366 5.0332 5.576
NCI-H1755 CTRP2 5.4454 6.3815 5.2754 4.6128
A-549 CTRP2 5.4569 6.2435 5.3396 4.3364
NCI-H1944 CTRP2 5.5196 14.2659 1.4885 19.4997
LCLC-97TM1 CTRP2 5.5346 6.6528 5.2543 4.4568
NCI-H460 CTRP2 5.5371 6.2577 5.4208 3.8014
NCI-H2170 CTRP2 5.5469 10.2176 3.53 11.5548
DMS 114 CTRP2 5.5511 10.1261 3.5792 11.3423
NCI-H1666 CTRP2 5.5694 6.4018 5.3983 3.7982
NCI-H1184 CTRP2 5.5706 7.2673 5.004 5.3827
NCI-H841 CTRP2 5.5764 10.6417 3.3449 12.2557
NCI-H1435 CTRP2 5.586 7.3278 4.9897 5.4051
SHP-77 CTRP2 5.6452 7.4869 4.9684 5.3573
ChaGo-K-1 CTRP2 5.6602 10.131 3.6727 10.7258
NCI-H1694 CTRP2 5.6732 6.4133 5.5016 3.1164
NCI-H69 CTRP2 5.6885 11.6483 2.9406 13.6686
NCI-H889 CTRP2 5.7044 9.6956 3.9283 9.5697
NCI-H2023 CTRP2 5.7206 6.3935 5.559 2.7656
NCI-H441 CTRP2 5.7326 6.4994 5.5239 2.8747
NCI-H2286 CTRP2 5.7361 6.5279 5.5143 2.9046
NCI-H727 CTRP2 5.7455 9.6931 3.9653 9.3302
SK-LU-1 CTRP2 5.7718 6.5333 5.5473 2.6829
NCI-H1573 CTRP2 5.779 7.2184 5.2238 3.9979
NCI-H1373 CTRP2 5.7791 6.9323 5.3638 3.4176
NCI-H2172 CTRP2 5.8274 6.4734 5.6302 2.2106
NCI-H1792 CTRP2 5.8297 6.7041 5.5221 2.6479
HCC1588 CTRP2 5.867 6.8523 5.4846 2.7195
VMRC-LCD CTRP2 5.8831 10.0358 3.9128 9.2712
EPLC-272H CTRP2 5.8835 6.8965 5.4778 2.7116
NCI-H2444 CTRP2 5.9216 9.2506 4.3378 7.4132
NCI-H1651 CTRP2 5.9372 7.6035 5.1738 3.8715
NCI-H1385 CTRP2 6.0246 11.6498 3.2252 11.8395
NCI-H2106 CTRP2 6.241 14.2954 2.0815 15.8993
NCI-H2126 CTRP2 6.2719 7.6808 5.4071 2.2703
NCI-H2029 CTRP2 6.4109 8.8819 4.9183 4.0713
DMS 454 CTRP2 6.4485 10.5757 4.1061 7.3967
LC-1/sq-SF CTRP2 6.4507 11.1527 3.8204 8.5823
DMS 79 CTRP2 6.4856 9.0897 4.872 4.1391
NCI-H1623 CTRP2 6.5079 10.0532 4.4119 6.0169
HCC1833 CTRP2 6.5406 9.5907 4.6659 4.9041
COLO 699 CTRP2 6.5858 9.2252 4.8795 3.9454
LUDLU-1 CTRP2 6.5974 10.8769 4.0721 7.2778
RERF-LC-Ad2 CTRP2 6.6162 13.6154 2.7243 12.7317
NCI-H2196 CTRP2 6.8093 12.4114 3.4737 9.3814
NCI-H1092 CTRP2 6.9446 14.2499 2.6656 12.3729
COR-L95 CTRP2 6.9762 8.7922 5.3475 1.5448
HCC2935 CTRP2 7.1091 10.3898 4.6822 3.9674
BEN CTRP2 7.4067 8.5859 5.6516 0.2719
NCI-H322 CTRP2 7.5359 13.2149 3.6133 7.6451
NCI-H1869 CTRP2 7.6411 12.4936 4.0338 5.8129
EBC-1 CTRP2 7.674 17.193 1.763 14.4719
NCI-H2342 CTRP2 9.1209 18.9826 1.9249 11.6738
NCI-H2141 CTRP2 9.4118 39.142 -7.7886 31.3349
Hs 888.Lu CTRP2 1.6484 9.4528 0.0234 34.1506
⏷ Show the Full List of 138 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 3.3855 6.5942 2.9758 19.1719
P-STS CTRP2 4.9473 10.0324 3.0757 14.733
SYO-1 CTRP2 5.609 16.0845 0.657 22.0401
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 3.9606 5.4127 3.9064 14.0667
OVCAR-5 CTRP2 1.2873 3.7858 1.2531 31.8065
TOV-112D CTRP2 1.3126 4.042 1.2587 31.7034
JHOM-1 CTRP2 1.954 10.6532 -0.1742 33.6598
SNU-119 CTRP2 2.3261 5.895 2.0263 25.8064
OV-90 CTRP2 2.5468 4.0588 2.5383 23.3296
OAW42 CTRP2 2.7072 3.8008 2.706 22.2367
OV56 CTRP2 2.7334 5.2283 2.6166 22.4571
OV7 CTRP2 3.2328 6.7873 2.7453 20.4714
EFO-21 CTRP2 3.267 7.4147 2.5536 21.0836
COV362 CTRP2 3.4801 9.2276 2.0157 22.4865
OVSAHO CTRP2 3.5204 6.7178 3.0805 18.389
JHOC-5 CTRP2 3.542 5.1776 3.492 16.8407
Kuramochi CTRP2 3.6272 6.5957 3.2377 17.4934
TOV-21G CTRP2 4.0084 6.9363 3.528 15.3072
OVTOKO CTRP2 4.0569 8.7965 2.7939 18.0209
FU-OV-1 CTRP2 4.1439 6.3351 3.8843 13.5823
SNU-8 CTRP2 4.5869 4.9324 4.5869 9.7099
A2780 CTRP2 4.6266 5.3739 4.6162 9.4804
OVISE CTRP2 4.6657 22.4165 -3.3172 32.9582
OVCAR-8 CTRP2 4.6935 5.7023 4.6475 9.157
COV434 CTRP2 4.869 7.7828 4.0717 10.8796
COV644 CTRP2 4.8787 7.4783 4.2188 10.2666
MCAS CTRP2 4.9317 5.9517 4.8541 7.6824
HEY A8 CTRP2 5.2922 5.7996 5.2751 5.0692
OC 314 CTRP2 5.3743 8.2022 4.3664 8.4629
OVK18 CTRP2 5.4105 6.0612 5.348 4.4422
ONCO-DG-1 CTRP2 5.4237 9.9998 3.5283 11.8247
JHOS-2 CTRP2 5.4273 10.4899 3.2885 12.8032
IGROV-1 CTRP2 5.4373 6.2268 5.3244 4.4502
OAW28 CTRP2 5.6459 8.75 4.3466 7.9445
SK-OV-3 CTRP2 5.7483 6.3994 5.5848 2.5916
RMG-I CTRP2 5.7871 9.2051 4.2448 8.0754
TYK-nu CTRP2 5.7921 6.6204 5.5262 2.7196
Caov-3 CTRP2 5.8197 6.479 5.6199 2.2711
SNU-840 CTRP2 6.0535 7.0132 5.5675 1.987
OVCAR-4 CTRP2 6.3189 10.2037 4.1889 7.2834
EFO-27 CTRP2 7.3315 13.1915 3.4785 8.5014
DOV13 CTRP2 7.9834 18.7566 1.223 15.803
ES2 CTRP2 10.6609 29.258 -1.9762 20.4869
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 4.9283 7.8022 4.1222 10.5278
Yamato-SS CTRP2 5.1145 6.2184 4.9772 6.6838
HT-1080 CTRP2 -0.3764 2.1365 -0.3847 42.7996
TE 617.T CTRP2 0.2852 2.5258 0.278 38.3917
SK-LMS-1 CTRP2 0.5359 3.6297 0.4807 36.8728
SK-UT-1 CTRP2 1.5007 5.4544 1.2335 31.1584
G-402 CTRP2 1.5515 4.254 1.4894 30.1403
Hs 729.T CTRP2 2.0662 7.9218 1.0769 29.822
KYM-1 CTRP2 2.5767 2.9912 2.5767 23.1024
A-204 CTRP2 3.1273 5.7335 2.9401 20.0822
GCT CTRP2 3.6312 7.868 2.7587 19.2907
BT-16 CTRP2 3.7016 4.2675 3.7016 15.608
TTC-709 CTRP2 3.7622 5.118 3.7324 15.3048
RD CTRP2 3.7765 7.436 3.0874 17.635
TE 441.T CTRP2 3.7932 6.4368 3.4702 16.1456
SW982 CTRP2 3.8912 5.4234 3.8303 14.5523
Rh41 CTRP2 4.3251 5.168 4.3165 11.4832
MES-SA CTRP2 4.3965 7.8652 3.555 14.1486
BT-12 CTRP2 4.7219 6.2027 4.555 9.4009
G-401 CTRP2 4.7296 8.9174 3.4053 13.9124
Rh18 CTRP2 5.0262 5.9155 4.9656 6.9929
Tm87-16 CTRP2 5.1804 6.5767 4.917 6.7235
RKN CTRP2 5.4077 6.0738 5.3413 4.4751
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.0007 12.0673 2.9965 12.8147
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 -0.2189 2.7667 -0.2457 41.8019
NCI-H2052 CTRP2 1.1587 4.2856 1.0696 32.8429
NCI-H28 CTRP2 2.5789 4.4541 2.55 23.1847
IST-Mes1 CTRP2 2.7876 5.3582 2.6513 22.1642
NCI-H2452 CTRP2 2.8481 7.2141 2.1791 23.6747
ACC-MESO-1 CTRP2 4.3432 5.687 4.2718 11.5784
JL-1 CTRP2 7.2889 13.3261 3.3814 8.9589
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP2 4.2277 11.8086 1.5368 22.275
LNCaP clone FGC CTRP2 5.4167 7.7611 4.6197 7.3211
VCaP CTRP2 5.5702 9.3894 3.962 9.7108
22Rv1 CTRP2 5.5741 8.107 4.599 7.0489
DU145 CTRP2 6.4935 13.0859 2.8905 12.2998
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 2.3408 5.8956 2.0422 25.7044
A-253 CTRP2 8.7608 17.4938 2.3948 10.518
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LMSU CTRP2 -0.755 2.0045 -0.7662 45.3238
SNU-16 CTRP2 -0.2159 2.4948 -0.2313 41.7516
SNU-1 CTRP2 1.3226 3.9275 1.2792 31.6019
SH-10-TC CTRP2 1.7805 4.4414 1.7109 28.6405
GSS CTRP2 2.1731 3.8691 2.1629 25.8253
SNU-719 CTRP2 2.267 5.7829 1.9904 26.117
MKN1 CTRP2 2.4599 5.1089 2.3425 24.2807
ECC10 CTRP2 2.5969 4.4749 2.5671 23.0677
SNU-216 CTRP2 2.7098 3.9449 2.7068 22.2255
Hs 746.T CTRP2 2.7328 3.3957 2.7328 22.0622
SNU-5 CTRP2 3.3311 6.1946 1.7076 6.4198
SNU-668 CTRP2 3.6228 5.8733 3.4464 16.7459
NUGC-4 CTRP2 3.7303 5.5848 3.628 15.7681
SNU-620 CTRP2 3.784 4.9763 3.7674 15.1146
AGS CTRP2 3.8256 5.1817 3.7926 14.8931
ECC12 CTRP2 4.2229 5.2343 4.2056 12.193
NCI-N87 CTRP2 4.7814 5.9495 4.6908 8.7289
HGC-27 CTRP2 4.8223 6.578 4.5346 9.1858
NCC-StC-K140 CTRP2 4.8511 6.7003 4.5187 9.1658
23132/87 CTRP2 4.9672 6.0597 4.8646 7.536
KE-39 CTRP2 5.2733 9.3293 3.7221 11.3539
MKN74 CTRP2 5.4916 10.1527 3.5131 11.7417
HuG1-N CTRP2 5.6963 15.0306 1.258 19.9176
SNU-601 CTRP2 5.7157 7.8633 4.8483 5.7003
NUGC-3 CTRP2 5.8542 6.7495 5.523 2.5885
OCUM-1 CTRP2 5.9124 8.1 4.9046 5.0519
GSU CTRP2 6.0575 7.6881 5.2334 3.3838
MKN45 CTRP2 6.1472 7.0783 5.6104 1.6352
IM95 CTRP2 6.4836 16.291 1.2823 18.2658
Fu97 CTRP2 6.6537 10.298 4.4015 5.8142
MKN7 CTRP2 7.0286 10.9389 4.3609 5.386
SNU-685 CTRP2 1.2659 2.7751 1.2646 31.8393
SNU-1077 CTRP2 3.0811 4.1842 3.0784 19.7507
SNG-M CTRP2 5.1184 5.9228 5.0643 6.3559
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 -0.3864 2.0117 -0.3924 42.8601
CAL-62 CTRP2 0.5911 1.1587 0.5911 36.3303
8505C CTRP2 0.7933 4.2548 0.6847 35.3301
SW579 CTRP2 1.7985 4.6562 1.7027 28.6096
ML-1 [Human leukemia] CTRP2 3.1081 5.1382 3.0341 19.8136
FTC-133 CTRP2 3.1328 10.1202 1.2626 26.0636
TT2609-C02 CTRP2 3.1862 8.9765 1.8252 23.9808
B-CPAP CTRP2 3.4982 4.7753 3.4838 17.0113
BHT-101 CTRP2 4.1299 8.0854 3.1848 16.3031
8305C CTRP2 4.5592 6.0749 4.4151 10.3996
CGTH-W-1 CTRP2 4.6045 5.8393 4.5238 9.8712
TT CTRP2 5.0261 7.2534 4.4691 8.891
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-8 CTRP2 1.4683 5.4545 1.1982 31.3815
PE/CA-PJ49 CTRP2 1.8832 3.3253 1.8808 27.7305
SCC-9 CTRP2 2.2384 6.6025 1.7259 27.1262
SNU-1214 CTRP2 2.2656 4.5154 1.5941 9.7958
SNU-46 CTRP2 2.6363 5.8752 2.3698 23.6292
SNU-899 CTRP2 2.6822 5.179 2.57 22.7822
HSC-2 CTRP2 2.8918 6.168 2.5694 22.1315
CAL-27 CTRP2 3.5591 5.5738 3.4446 16.9509
SNU-1041 CTRP2 3.6597 7.1336 3.0803 17.9894
SCC-4 CTRP2 3.7652 5.8303 3.6121 15.7152
HSC-3 CTRP2 3.954 5.5234 3.8813 14.1748
BICR 18 CTRP2 4.1666 7.4653 3.487 15.0263
YD-10B CTRP2 4.1991 5.9273 4.0613 12.7727
PE/CA-PJ34 (clone C12) CTRP2 4.2059 7.5798 3.4803 14.9463
CAL-33 CTRP2 4.4667 7.6499 3.7211 13.3099
SNU-1076 CTRP2 4.817 5.3088 4.8152 8.1831
Detroit 562 CTRP2 4.8745 6.6193 4.5749 8.8854
FaDu CTRP2 4.9709 8.3336 3.9164 11.2568
BICR 6 CTRP2 4.9737 8.9488 3.6257 12.4359
SCC-25 CTRP2 5.0255 6.0766 4.9235 7.1458
SNU-1066 CTRP2 5.0439 6.8675 4.6543 8.1143
BICR 31 CTRP2 5.1322 9.2322 3.6385 12.0163
BHY CTRP2 5.2848 6.8501 4.9116 6.4644
BICR 22 CTRP2 5.3926 8.6205 4.1796 9.1936
PE/CA-PJ15 CTRP2 5.596 10.4905 3.4374 11.8339
BICR 56 CTRP2 5.6875 9.3256 4.0977 8.897
HSC-4 CTRP2 5.9087 7.7861 5.058 4.4156
BICR 16 CTRP2 6.4133 9.4897 4.6187 5.3174
PE/CA-PJ41 (clone D2) CTRP2 6.4427 11.667 3.5578 9.6842
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP2 -0.1373 1.8251 -0.139 41.1886
647V CTRP2 2.0013 3.0939 2.001 26.9366
TCCSUP CTRP2 2.2145 5.0744 2.084 25.9595
BC-3C CTRP2 2.6316 4.7985 2.5715 22.9397
T24 CTRP2 2.7255 6.8591 2.1711 24.0682
SCaBER CTRP2 3.3213 6.7705 2.8468 19.8369
KU-19-19 CTRP2 4.023 5.2705 3.9916 13.5729
JMSU-1 CTRP2 4.0577 5.0472 4.0469 13.2722
UM-UC-1 CTRP2 4.3582 8.1661 3.3825 14.9302
253J CTRP2 4.4012 5.5191 4.3624 11.0789
U-BLC1 CTRP2 4.5361 6.4606 4.2685 11.0076
639V CTRP2 4.6688 5.7536 4.6114 9.3609
SW1710 CTRP2 4.9677 5.8807 4.9097 7.3731
J82 CTRP2 5.1966 8.7221 3.9468 10.601
RT-112 CTRP2 5.5167 5.9794 5.4848 3.6259
UM-UC-3 CTRP2 5.6866 6.2593 5.5797 2.7758
VM-CUB-1 CTRP2 5.7167 9.2228 4.1745 8.5148
HT-1376 CTRP2 5.7949 8.7185 4.4941 7.0142
KMBC-2 CTRP2 5.9658 10.435 3.7833 9.6484
RT-4 CTRP2 6.9045 9.1647 5.1296 2.4673
HT-1197 CTRP2 7.1624 11.5692 4.1492 6.0455
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 5.0892 6.1528 4.9704 6.7836

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Fluvastatin
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Bempedoic acid DM1CI9R Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Bempedoic acid. Hyper-lipoproteinaemia [5C80] [18]
Mipomersen DMGSRN1 Major Increased risk of hepatotoxicity by the combination of Fluvastatin and Mipomersen. Hyper-lipoproteinaemia [5C80] [19]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Fluvastatin and Teriflunomide. Hyper-lipoproteinaemia [5C80] [20]
BMS-201038 DMQTAGO Major Increased risk of hepatotoxicity by the combination of Fluvastatin and BMS-201038. Hyper-lipoproteinaemia [5C80] [21]
Coadministration of a Drug Treating the Disease Different from Fluvastatin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [22]
Midostaurin DMI6E0R Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Midostaurin. Acute myeloid leukaemia [2A60] [23]
Arn-509 DMT81LZ Moderate Accelerated clearance of Fluvastatin due to the transporter induction by Arn-509. Acute myeloid leukaemia [2A60] [23]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [24]
Ag-221 DMS0ZBI Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Ag-221. BCR-ABL1-negative chronic myeloid leukaemia [2A41] [22]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Fluvastatin and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [25]
Alpelisib DMEXMYK Moderate Increased metabolism of Fluvastatin caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [26]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Fluvastatin caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [27]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Fluvastatin caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [22]
MK-8228 DMOB58Q Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by MK-8228. Cytomegaloviral disease [1D82] [28]
Stiripentol DMMSDOY Moderate Decreased metabolism of Fluvastatin caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [22]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Cannabidiol. Epileptic encephalopathy [8A62] [23]
GS-9857 DMYU6P5 Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by GS-9857. Hepatitis virus infection [1E50-1E51] [29]
Rifapentine DMCHV4I Moderate Increased metabolism of Fluvastatin caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [30]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Brentuximab vedotin. Hodgkin lymphoma [2B30] [31]
Fostemsavir DM50ILT Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [32]
Cobicistat DM6L4H2 Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Cobicistat. Human immunodeficiency virus disease [1C60-1C62] [22]
Etravirine DMGV8QU Moderate Decreased metabolism of Fluvastatin caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [22]
Ceritinib DMB920Z Moderate Decreased metabolism of Fluvastatin caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [23]
PF-06463922 DMKM7EW Moderate Increased metabolism of Fluvastatin caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [22]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [33]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Fluvastatin and Idelalisib. Mature B-cell leukaemia [2A82] [34]
Vemurafenib DM62UG5 Moderate Decreased metabolism of Fluvastatin caused by Vemurafenib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [22]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Fluvastatin caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [22]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Fluvastatin caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [22]
Abametapir DM2RX0I Moderate Decreased metabolism of Fluvastatin caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [35]
Lefamulin DME6G97 Moderate Decreased metabolism of Fluvastatin caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [36]
ABIRATERONE DM8V75C Moderate Decreased metabolism of Fluvastatin caused by ABIRATERONE mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [22]
Enzalutamide DMGL19D Moderate Increased metabolism of Fluvastatin caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [37]
Darolutamide DMV7YFT Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Darolutamide. Prostate cancer [2C82] [23]
Leflunomide DMR8ONJ Major Increased risk of hepatotoxicity by the combination of Fluvastatin and Leflunomide. Rheumatoid arthritis [FA20] [20]
Larotrectinib DM26CQR Moderate Decreased metabolism of Fluvastatin caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [22]
Fostamatinib DM6AUHV Moderate Decreased clearance of Fluvastatin due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [38]
⏷ Show the Full List of 33 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Benzyl alcohol E00010 244 Antimicrobial preservative; Solvent
Butylparaben E00142 7184 Antimicrobial preservative
Calcium carbonate E00198 10112 Binding agent; Buffering agent; Diluent; Opacifying agent
methylparaben E00149 7456 Antimicrobial preservative
Propyl 4-hydroxybenzoate E00141 7175 Antimicrobial preservative
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Ammonia E00007 222 Alkalizing agent
Carboxymethylcellulose sodium E00621 Not Available Adsorbent; Binding agent; Disintegrant; Emulsifying agent; Suspending agent; Viscosity-controlling agent
Crospovidone E00626 Not Available Disintegrant
Edetate calcium disodium E00487 6093170 Complexing agent
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Hydroxypropyl cellulose E00632 Not Available Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Potassium bicarbonate E00425 516893 Alkalizing agent
Potassium hydroxide E00233 14797 Alkalizing agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium bicarbonate E00424 516892 Alkalizing agent; Diluent
Sodium propionate E00445 2723816 Antimicrobial preservative
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Colcothar yellow E00436 518696 Colorant
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
Hydroxyethyl cellulose E00700 Not Available Coating agent; Suspending agent; Binding agent; Viscosity-controlling agent
⏷ Show the Full List of 33 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Fluvastatin 20 mg capsule 20 mg Oral Capsule Oral
Fluvastatin 40 mg capsule 40 mg Oral Capsule Oral
Fluvastatin Sodium eq 80mg base extended release tablet eq 80mg base Extended Release Tablet Oral
Fluvastatin 80 mg tablet 80 mg 24 HR Extended Release Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Fluvastatin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2951).
3 BDDCS applied to over 900 drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
7 Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64.
8 Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14.
9 Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates. Pharm Res. 2015 May;32(5):1634-47.
10 SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. Clin Pharmacol Ther. 2006 Oct;80(4):356-66.
11 A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26.
12 Effects of fluvastatin on the pharmacokinetics of eepaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by fluvastatin. Korean J Physiol Pharmacol. 2013 Jun;17(3):245-51.
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14 Limitations of S-warfarin truncated area under the concentration-time curve to predict cytochrome P450 2c9 activity. Drug Metab Lett. 2012 Jun 1;6(2):94-101.
15 Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver. Drug Metab Dispos. 1996 Nov;24(11):1197-204.
16 Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics. 2004 Aug;14(8):523-5.
17 Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8.
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28 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
29 Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
30 Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
31 Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
32 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
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34 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
35 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
36 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
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