Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF70AB)

Drug Name
Ginsenoside Rb1 Drug Info
Synonyms
Arasaponin E1; Ginsenoside rb1; Gynosaponin C; Panax saponin E; Panaxsaponin E; Pseudoginsenoside D; Sanchinoside E1; ginsenoside-Rb1; (20S)-ginsenoside Rb1; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside; 20(S)-ginsenoside Rb1; 41753-43-9; 7413S0WMH6; BIDD:ER0108; C54H92O23; CHEBI:67989; CHEMBL501515; GRb 1; GS-Rb1; GSRb1; GZYPWOGIYAIIPV-JBDTYSNRSA-N; Gypenoside III; NSC 310103; UNII-7413S0WMH6
Cross-matching ID
PubChem CID
9898279
ChEBI ID
CHEMBL67989
CAS Number
CAS 41753-43-9
TTD Drug ID
DMF70AB
INTEDE Drug ID
DR2669

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Beta-glucosidase (bglA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SC-46553 DM6XNJR N. A. N. A. Phase 3 [3]
HY-N0040 DM349AM N. A. N. A. Preclinical [3]
SC-46553 DM6XNJR N. A. N. A. Phase 3 [3]
HY-N0040 DM349AM N. A. N. A. Preclinical [3]
SC-46553 DM6XNJR N. A. N. A. Phase 3 [4] , [3]
HY-N0040 DM349AM N. A. N. A. Preclinical [3]
SC-46553 DM6XNJR N. A. N. A. Phase 3 [5]
Ginsenoside Re DM46FVD N. A. N. A. Investigative [5]
Ginsenoside Rg1 DMYE2SR N. A. N. A. Investigative [5]
HY-N0040 DM349AM N. A. N. A. Preclinical [1]
Ginsenoside Rc DMES9Q2 N. A. N. A. Investigative [1]
Glucopyranosyl oleanolate DMRHYU8 N. A. N. A. Investigative [3]
Gypenoside XVII DM8ENQZ N. A. N. A. Investigative [3]
HY-N0040 DM349AM N. A. N. A. Preclinical [1]
CCG-208408 DMCFEUG N. A. N. A. Preclinical [8]
Ginsenoside Rc DMES9Q2 N. A. N. A. Investigative [1]
DB-041901 DM7JV4O N. A. N. A. Phase 2 [9]
⏷ Show the Full List of 17 Drug(s)
Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Pentobarbital DMFNH7L Brain ischaemia 8B1Z Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [13]
Propranolol DM79NTF Angina pectoris BA40 Approved [13]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [13]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [13]
Quinidine DMLPICK N. A. N. A. Approved [13]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [13]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-glucosidase (bglA) DEUQTKA A0A249DCH3_LACRH Substrate [1]
Beta-glucosidase (bglA) DEE8WXK A0A076JJU4_BIFAD Substrate [2]
Beta-glucosidase (bglA) DEUO7V8 A0A509DD13_9STRE Substrate [3]
Beta-glucosidase (bglA) DE4LKZ9 A0A3D1ZWL4_9BIFI Substrate [3]
Beta-glucosidase (bglA) DEM6GYO A0A351PC96_9FIRM Substrate [4] , [3]
Beta-glucosidase (bglA) DE9N4OU C6WCL5_ACTMD Substrate [5]
Beta-glucosidase (bglA) DERPJZ6 A0A4Q4LS82_BIFAN Substrate [1]
Beta-glucosidase (bglA) DEVLXCG R7LVY8_9FUSO Substrate [3]
Beta-glucosidase (bglA) DEXRUS1 A0A267WL33_9BIFI Substrate [2]
Beta-glucosidase (bglA) DERX7ML A0A3B8TKP6_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEOHI3U A0A0P0FEZ9_BACT4 Substrate [2]
Beta-glucosidase (bglA) DE46IH1 A0A1T4QCU7_9PROT Substrate [6]
Beta-glucosidase (bglA) DECBSVP A0A126SWK8_9BIFI Substrate [2]
Beta-glucosidase (bglA) DEAVLU4 BGLFU_BIFBR Substrate [2]
Beta-glucosidase (bglA) DEPBQES BGLS_BUTFI Substrate [2]
Beta-glucosidase (bglA) DEGVUWH A0A174JG46_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEE8RS0 A0A174GPV4_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEC0M8H A0A174ZK85_9FIRM Substrate [2]
Beta-glucosidase (bglA) DE2OMS0 A0A173UNF6_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEPUNVR A0A395V8H8_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEX7SAW A0A3R6A2W5_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEE3I1P A0A412BAD0_9FIRM Substrate [2]
Beta-glucosidase (bglA) DEASJG5 A5ZMW4_9FIRM Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Potassium voltage-gated channel subfamily E member 1 (KCNE1) OTZNQUW9 KCNE1_HUMAN Gene/Protein Processing [7]

References

1 Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.
2 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
3 Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.
4 Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998 Oct;50(10):1155-60.
5 Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59.
6 Genus Enhydrobacter Staley et al. 1987 should be recognized as a member of the family Rhodospirillaceae within the class Alphaproteobacteria. Microbiol Immunol. 2012 Jan;56(1):21-6.
7 Ginsenosides may enhance the functionality of human embryonic stem cell-derived cardiomyocytes in vitro. Reprod Sci. 2014 Oct;21(10):1312-8. doi: 10.1177/1933719114525269. Epub 2014 Mar 10.
8 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
9 Gut microbiota-mediated drug-antibiotic interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9.
10 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
11 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
12 Inhibition of cardiac potassium currents by pentobarbital. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan;365(1):29-37. doi: 10.1007/s00210-001-0490-1. Epub 2001 Nov 8.
13 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.