Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF7JPO)

Drug Name

5'-Deoxy-5'-(N,N-dimethylamino)adenosine Drug Info

Synonyms

5'-Deoxy-5'-(Dimethylamino)adenosine; 5'-Deoxy-5'-(N,N-dimethylamino)adenosine; SCHEMBL952928; CHEMBL472733; AdoMet substrate analogue, 23b; BDBM28453; SLNWRDWGFHZRAQ-WOUKDFQISA-N; ZINC40914070; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-[(dimethylamino)methyl]oxolane-3,4-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 25231309
TTD Drug ID: DMF7JPO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tromethamine	DMOBLGK	Acidosis	5C73	Approved	[2]
ORG 34517/34850	DMR3P98	Mood disorder	6A60-6E23	Phase 2	[3]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[2]
MGBG	DM9GOT6	Head and neck cancer	2D42	Terminated	[3]
CGP-40215A	DM69YWS	Pneumocystis pneumonia	CA40.20	Terminated	[4]
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine	DM6HGUL	Discovery agent	N.A.	Investigative	[5]
Hydroxyalanine	DM5HWZY	Discovery agent	N.A.	Investigative	[6]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride	DM1NAMK	Discovery agent	N.A.	Investigative	[1]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine	DM3WDOY	Discovery agent	N.A.	Investigative	[1]
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine	DMT6D5V	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[1]

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References

1	New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
4	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
5	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.