Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFGQ2S)

Drug Name

Erythrityl Tetranitrate Drug Info

Synonyms

Cardilate; Cardiloid; Cardivell; Cardiwell; Erythritetranitrat; Nitroerythrit; Nitroerythrite; Nitroerythrol; Tetranitrin; Tetranitrol; Eritritile tetranitrato; Eritritile tetranitrato [DCIT]; Eritrityl tetranitrate; Eritrityli tetranitras; Erythritol tetranitrate; Erythrityl tetranitrate [USAN]; Erythrol tetranitrate; Tetranitrato de eritritilo; Eritrityli tetranitras [INN-Latin]; Erythritol, tetranitrate; Meso-Erythritol tetranitrate; Tetranitrate d'erithrityle; Tetranitrate d'eritrityle; Tetranitrato de eritritilo [INN-Spanish]; Erythritol, tetranitrate (8CI); Tetranitrate d'eritrityle [INN-French]; 1,2,3,4-Butanetetralyl tetranitrate; 1,3,4-trinitrooxybutan-2-yl nitrate

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Approved	[1]

Therapeutic Class

Vasodilator Agents

Cross-matching ID

PubChem CID: 5284553
ChEBI ID: CHEBI:60072
CAS Number: CAS 7297-25-8
TTD Drug ID: DMFGQ2S

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Guanylate cyclase (GC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[2]
Isosorbide Dinitrate	DMBI4JG	Anal fissure	DB50.0	Approved	[2]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[3]
Isosorbide Mononitrate	DMYLMU0	Angina pectoris	BA40	Approved	[2]
Pirsidomine	DMHI6GE	Angina pectoris	BA40	Phase 2	[4]
IW-1701	DM457XO	Sickle-cell disorder	3A51	Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Guanylate cyclase (GC)	TT6HPVC	NOUNIPROTAC	Stimulator	[2]

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References

1	Drug information of Erythrityl Tetranitrate, 2008. eduDrugs.
2	Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201.
3	Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82.
4	Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.
5	Clinical pipeline report, company report or official report of Cyclerion Therapeutics.