Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFOIA8)

Drug Name
Nesiritide Drug Info
Synonyms Natrecor (TN)
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Approved [1]
Cross-matching ID
PubChem CID
71308561
ChEBI ID
CHEBI:135919
TTD Drug ID
DMFOIA8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Atrial natriuretic peptide receptor A (NPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ularitide DM90AG2 Acute heart failure BD10-BD13 Phase 3 [3]
Ataciguat DM35KDA Neuropathic pain 8E43.0 Phase 2 [4]
Cenderitide DMCT8EY Heart disease BA41-BA42 Phase 2 [5]
PL-3994 DMHUCQS Asthma CA23 Phase 2 [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Atrial natriuretic peptide receptor A (NPR1) TTJME02 ANPRA_HUMAN Binder [2]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9.
3 Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
4 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
5 2011 Pipeline of Nile Therapeutics.
6 In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238.