Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFTW0U)

Drug Name
RO116-4875/608 Drug Info
Synonyms RO116-4875/608; GTPL789; SCHEMBL1223356; FQHUEFRHSWYBQS-QHCPKHFHSA-N; 1-[(2R)-1-[4-[(3,4-dichlorophenyl)methyl]piperidin-1-yl]-3-methylbutan-2-yl]-3-(3,4,5-trimethoxyphenyl)urea
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10098735
TTD Drug ID
DMFTW0U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting CCR3 messenger RNA (CCR3 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ASM8 DMTHR4U Allergic asthma CA23.0 Phase 2 [3]
banyu (I) DM9JXIZ Discovery agent N.A. Investigative [4]
RO116-9132/238 DM6XM1D Discovery agent N.A. Investigative [2]
RO320-2947/001 DM8BLYO Discovery agent N.A. Investigative [2]
RO330-0802/001 DMGOPY1 Discovery agent N.A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CCR3 messenger RNA (CCR3 mRNA) TTU3Y87 CCR3_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 789).
2 Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 60).
4 Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002 Dec 5;456(1-3):1-10.