Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG706J)

Drug Name

Lobatamide D Drug Info

Synonyms

Lobatamide E

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Vacuolar-type proton ATPase (v-ATPase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
WY-47766	DM7VCDZ	Osteoporosis	FB83.0	Discontinued in Phase 2	[2]
SB 242784	DMFXJDL	Arterial calcification	BD52.Y	Preclinical	[3]
Salicylihalamide A	DMGXVRZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
FR167356	DMF53Z7	Osteoporosis	FB83.0	Preclinical	[4]
Lobatamide A	DM2GBEW	Discovery agent	N.A.	Investigative	[1]
Lobatamide C	DMFIDJS	Discovery agent	N.A.	Investigative	[1]
Oximidine II	DMW6K80	Discovery agent	N.A.	Investigative	[1]
Lobatamide B	DMD91RI	Discovery agent	N.A.	Investigative	[1]
Oximidine I	DMG6O0L	Discovery agent	N.A.	Investigative	[1]
Lobatamide F	DM6BWGQ	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vacuolar-type proton ATPase (v-ATPase)	TTTK3BH	NOUNIPROTAC	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20.
2	A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase. Bone Miner. 1994 Nov;27(2):159-66.
3	SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20;91(6):547-52.
4	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.