Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTK3BH)

DTT Name Vacuolar-type proton ATPase (v-ATPase)
Synonyms Vacuolar-ATPase; Vacuolar ATPase; V-ATPase
Gene Name v-ATPase
DTT Type
Preclinical target
 [1]
BioChemical Class
Acid anhydrides hydrolase
UniProt ID
NOUNIPROTAC
TTD ID
T20103

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
WY-47766 DM7VCDZ Osteoporosis FB83.0 Discontinued in Phase 2 [1]
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3 Preclinical Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
FR167356 DMF53Z7 Osteoporosis FB83.0 Preclinical [2]
Salicylihalamide A DMGXVRZ Solid tumour/cancer 2A00-2F9Z Preclinical [3]
SB 242784 DMFXJDL Arterial calcification BD52.Y Preclinical [4]
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9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bafilomycin A1 DMUNK59 B-cell acute lymphoblastic leukaemia 2B33.3 Investigative [5]
BRD1240 DMIZ9ON Solid tumour/cancer 2A00-2F9Z Investigative [6]
Lobatamide A DM2GBEW Discovery agent N.A. Investigative [3]
Lobatamide B DMD91RI Discovery agent N.A. Investigative [3]
Lobatamide C DMFIDJS Discovery agent N.A. Investigative [3]
Lobatamide D DMG706J Discovery agent N.A. Investigative [3]
Lobatamide F DM6BWGQ Discovery agent N.A. Investigative [3]
Oximidine I DMG6O0L Discovery agent N.A. Investigative [3]
Oximidine II DMW6K80 Discovery agent N.A. Investigative [3]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase. Bone Miner. 1994 Nov;27(2):159-66.
2 Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
3 Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20.
4 SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20;91(6):547-52.
5 Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782.
6 Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.