Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG7EPF)

Drug Name

2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl Drug Info

Synonyms

CHEMBL1270043; SCHEMBL15511567; BDBM50329699; 2,2'',3-Tribromo-4,4'',5,5''-tetrahydroxybibenzyl

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mycobacterium Isocitrate lyase (MycB icl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrohalisulfate 1	DM0HQF6	Discovery agent	N.A.	Investigative	[2]
Halisulfate 1	DMJB87Q	Discovery agent	N.A.	Investigative	[2]
Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether	DMQ7KR1	Discovery agent	N.A.	Investigative	[1]
3-bromopyruvate	DMYL3ST	Discovery agent	N.A.	Investigative	[3]
Bis(3-bromo-4,5-dihydroxyphenyl)methanone	DMUN50H	Discovery agent	N.A.	Investigative	[1]
5,5'-methylenebis(3,4-dibromobenzene-1,2-diol)	DMZ693W	Discovery agent	N.A.	Investigative	[1]
Glyoxalate, Glyoxylate	DMQUP7O	Discovery agent	N.A.	Investigative	[4]
3-nitropropionate	DMH798G	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Isocitrate lyase (MycB icl)	TT58ZYW	ACEA_MYCTU	Inhibitor	[1]

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References

1	Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8.
2	Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6.
3	Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.