Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGN4OQ)

Drug Name

ISIS-1939 Drug Info

Synonyms

136216-59-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Intercellular adhesion molecule ICAM-1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
lifitegrast	DM4WVC5	Dry eye disease	9E1Z	Approved	[2]
Alicaforsen	DMQ509J	Lleum inflammation	1A40.0	Phase 3	[3]
BI-505	DMSZQHX	Multiple myeloma	2A83	Phase 2	[4]
APC-8015F	DM3VP19	Prostate cancer	2C82.0	Phase 2	[5]
AIC100	DMSPBOW	Thyroid cancer	2D10	Phase 1	[6]
GI-270384X	DM3KN2Q	Inflammatory bowel disease	DD72	Terminated	[7]
A-252444.0	DMDTA36	Inflammation	1A00-CA43.1	Terminated	[8]
MOR-102	DMRCH1M	Psoriasis vulgaris	EA90	Terminated	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intercellular adhesion molecule ICAM-1 (ICAM1)	TTCT6F7	ICAM1_HUMAN	Modulator	[1]

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References

1	Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem. 1991 Sep 25;266(27):18162-71.
2	Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013 Apr 15;23(4):502-15.
5	National Cancer Institute Drug Dictionary (drug id 561410).
6	Clinical pipeline report, company report or official report of AffyImmune Therapeutics.
7	Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566)
9	Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005 Oct;153(4):758-66.