Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGP8WX)

Drug Name
ANG-3777 Drug Info
Synonyms
Terevalefim; Refanalin; Terevalefim [INN]; ANG-3777; 1070881-42-3; Terevalefim [USAN]; SNV-003; 500128-99-4; GG91UXK2M5; Terevalefim [USAN:INN]; UNII-GG91UXK2M5; 5-((E)-2-Thiophen-2-yl-vinyl)-lh-pyrazole; 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole; (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole; WHO 11458; 3-[2-(2-thienyl)ethenyl]-1H-Pyrazole; 1H-Pyrazole, 3-((1E)-2-(2-thienyl)ethenyl)-; BB3; TEREVALEFIM [WHO-DD]; BB-3; SCHEMBL1225335; CHEMBL4650326; SCHEMBL10149623; GTPL11997; ANG3777; GLXC-26914; AKOS040755926; MS-22944; HY-137455; 5-[2-(thiophen-2-yl)ethenyl]-1H-pyrazole; CS-0138662; E80357; (E)-3-(2-(thiophen-2-yl)vinyl)-1H-pyrazole; EN300-7830322; 5-[(E)-2-(thiophen-2-yl)ethenyl]-1H-pyrazole; EN300-18541705
Indication
Disease Entry ICD 11 Status REF
Delayed graft function 4B24.0 Phase 3 [1]
Cross-matching ID
PubChem CID
5714038
TTD Drug ID
DMGP8WX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VM-202 DMSW80U Angina pectoris BA40 Phase 3 [3]
Donaperminogene seltoplasmid DMH8IT5 Diabetic foot ulcer BD54 Phase 3 [4]
Ficlatuzumab DMG65WH Multiple myeloma 2A83 Phase 2 [5]
Collategene DM27H0P Peripheral Ischemic Ulcers BD41 Phase 2 [6]
MP0250 DMR3VCY Non-small-cell lung cancer 2C25.Y Phase 1/2 [5]
ABI-011 DM1KD7U Lymphoma 2A80-2A86 Phase 1 [5]
TAK-701 DML3M0O Advanced malignancy 2A00-2F9Z Phase 1 [7]
Rilotumumab DMD8ZSW Grade IV malignant glioma 2A00.0 Discontinued in Phase 2 [8]
N,O6-Disulfo-Glucosamine DMYCV7U Discovery agent N.A. Investigative [9]
O2-Sulfo-Glucuronic Acid DME78MS Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatocyte growth factor (HGF) TT4V2JM HGF_HUMAN Mimetic [2]

References

1 ClinicalTrials.gov (NCT02474667) A Multicenter, Prospective, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study of ANG-3777 (Formerly BB3) to Improve Graft Function and Reduce the Severity of Kidney Dysfunction or Delayed Graft Function Following Kidney Transplantation in Recipients of a Deceased Donor Kidney. U.S.National Institutes of Health.
2 Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery-Associated Acute Kidney Injury. Kidney Int Rep. 2020 Sep 25;5(12):2325-2332.
3 Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model. Eur J Cardiothorac Surg. 2008 Oct;34(4):857-63.
4 Clinical pipeline report, company report or official report of ViroMed.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Ther. 2010 Sep;17(9):1152-61.
7 Targeting MET in cancer: rationale and progress.Nat Rev Cancer.2012 Jan 24;12(2):89-103.
8 Clinical pipeline report, company report or official report of Amgen (2009).
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.