Details of the Drug

General Information of Drug (ID: DMGP8WX)

Drug Name
ANG-3777
Synonyms
Terevalefim; Refanalin; Terevalefim [INN]; ANG-3777; 1070881-42-3; Terevalefim [USAN]; SNV-003; 500128-99-4; GG91UXK2M5; Terevalefim [USAN:INN]; UNII-GG91UXK2M5; 5-((E)-2-Thiophen-2-yl-vinyl)-lh-pyrazole; 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole; (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole; WHO 11458; 3-[2-(2-thienyl)ethenyl]-1H-Pyrazole; 1H-Pyrazole, 3-((1E)-2-(2-thienyl)ethenyl)-; BB3; TEREVALEFIM [WHO-DD]; BB-3; SCHEMBL1225335; CHEMBL4650326; SCHEMBL10149623; GTPL11997; ANG3777; GLXC-26914; AKOS040755926; MS-22944; HY-137455; 5-[2-(thiophen-2-yl)ethenyl]-1H-pyrazole; CS-0138662; E80357; (E)-3-(2-(thiophen-2-yl)vinyl)-1H-pyrazole; EN300-7830322; 5-[(E)-2-(thiophen-2-yl)ethenyl]-1H-pyrazole; EN300-18541705
Indication
Disease Entry ICD 11 Status REF
Delayed graft function 4B24.0 Phase 3 [1]
Drug Type
Small molecule
Structure
3D MOL is unavailable 2D MOL
Chemical Identifiers
Formula
C9H8N2S
Canonical SMILES
C1=CSC(=C1)C=CC2=CC=NN2
InChI
InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+
InChIKey
FOHWAQGURRYJFK-ONEGZZNKSA-N
Cross-matching ID
PubChem CID
5714038
UNII
GG91UXK2M5
DrugBank ID
DB16397
TTD ID
D5E2KR
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatocyte growth factor (HGF) TT4V2JM HGF_HUMAN Mimetic [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Delayed graft function
ICD Disease Classification 4B24.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Hepatocyte growth factor (HGF) DTT HGF 4.90E-01 0.13 2.73
Hepatocyte growth factor (HGF) DTT HGF 1.98E-07 1.58 2.92
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT02474667) A Multicenter, Prospective, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study of ANG-3777 (Formerly BB3) to Improve Graft Function and Reduce the Severity of Kidney Dysfunction or Delayed Graft Function Following Kidney Transplantation in Recipients of a Deceased Donor Kidney. U.S.National Institutes of Health.
2 Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery-Associated Acute Kidney Injury. Kidney Int Rep. 2020 Sep 25;5(12):2325-2332.