Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGSRN1)

Drug Name
Mipomersen Drug Info
Synonyms Mipomersen
Indication
Disease Entry ICD 11 Status REF
Familial hypercholesterolemia 5C80.00 Approved [1]
Therapeutic Class
Antisense
Cross-matching ID
PubChem CID
71301230
CAS Number
CAS 1000120-98-8
TTD Drug ID
DMGSRN1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting APOB messenger RNA (APOB mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TKM-ApoB DM2M47Y Hypercholesterolaemia 5C80.0 Phase 4 [3]
ISIS 147788 DM1Z5W8 Discovery agent N.A. Investigative [4]
ISIS 147483 DMNMXKC Discovery agent N.A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
APOB messenger RNA (APOB mRNA) TTN1IE2 APOB_HUMAN Not Available [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7364).
2 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
3 Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.
4 US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.