Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH6OPI)

Drug Name

4-Bromo-6-nitro-2-piperazin-1-yl-quinoline Drug Info

Synonyms

4-Bromo-6-nitroquipazine; 143954-73-8; CHEMBL167825; 4-Bromo-6-nitro-2-piperazin-1-yl-quinoline; Quinoline, 4-bromo-6-nitro-2-(1-piperazinyl)-; ACMC-20n3fo; SCHEMBL6364738; AC1L318Y; CTK0I3188; DTXSID50162581; NRCNLRMWSMFETI-UHFFFAOYSA-N; BDBM50110574

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 132590
CAS Number: CAS 143954-73-8
TTD Drug ID: DMH6OPI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[2]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[3]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[4]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[5]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[6]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[7]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[8]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[4]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[4]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5.
2	Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107.
3	Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
6	Psychopharmacological treatment of dermatological patients--when simply talking does not help. J Dtsch Dermatol Ges. 2007 Dec;5(12):1101-6.
7	Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
8	Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.