Details of the Drug

General Information of Drug (ID: DMK7F9S)

Drug Name
Amitriptyline
Synonyms
Adepress; Adepril; Amitril; Amitriprolidine; Amitriptilina; Amitriptylin; Amitriptylinum; Amitryptiline; Amitryptyline; Amytriptiline; Amytriptylin; Damilan; Damilen; Damitriptyline; Elanil; Elavil; Flavyl; Lantron; Laroxil; Laroxyl; Proheptadiene; Redomex; Sarotex; Seroten; Sylvemid; Triptanol; Triptilin; Triptisol; Tryptanol; Amitriptilina [Italian]; Amitriptylin [German]; MK 230; N 750; TP0; Amitriptilina [INN-Spanish]; Amitriptyline (INN); Amitriptyline [INN:BAN]; Amitriptylinum [INN-Latin]; Elavil (TN); Laroxyl (TN); Ro 4-1575; [3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine; 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine; 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine; 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene; 5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene; 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene; 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Pain MG30-MG3Z Approved [2]
Mixed anxiety and depressive disorder N.A. Investigative [2]
Sleep disorder, initiating and maintaining sleep N.A. Investigative [2]
Therapeutic Class
Analgesics
Affected Organisms
Humans and other mammals
ATC Code
N06AA09: Amitriptyline
N06AA: Non-selective monoamine reuptake inhibitors
N06A: ANTIDEPRESSANTS
N06: PSYCHOANALEPTICS
N: NERVOUS SYSTEM
N06AA09: Amitriptyline
N06AA: Non-selective monoamine reuptake inhibitors
N06A: ANTIDEPRESSANTS
N06: PSYCHOANALEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 277.4
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 1
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Bioavailability
The bioavailability of drug is 100% [4]
Clearance
The sytemic clearance of drug is 39.24 +/- 10.18 L/h [5]
Elimination
Virtually the entire dose is excreted as glucuronide or sulfate conjugate of metabolites, with approximately 2% of unchanged drug appearing in the urine []
Half-life
The concentration or amount of drug in body reduced by one-half in 25 hours []
Metabolism
The drug is metabolized via the demethylation (CYP2C19, CYP3A4) as well as hydroxylation (CYP2D6) followed by conjugation with glucuronic acid []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 15.4494 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.07% [7]
Vd
The volume of distribution (Vd) of drug is 1221 L +/- 280 L [5]
Water Solubility
The ability of drug to dissolve in water is measured as 1000 mg/mL [3]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Amitriptyline rs2032583 ABCB1 OTEJROBO [8]
Arrhythmia Not Available CYP2D6 OTZJC802 [9]
Atrioventricular block Not Available CYP3A4 OTQGYY83 [9]
Haemorrhage Not Available CYP2C19 OTFMJYYE [9]
Chemical Identifiers
Formula
C20H23N
IUPAC Name
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
Canonical SMILES
CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
InChI
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChIKey
KRMDCWKBEZIMAB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2160
ChEBI ID
CHEBI:2666
CAS Number
50-48-6
UNII
1806D8D52K
DrugBank ID
DB00321
TTD ID
D0Y5UG
VARIDT ID
DR00470
INTEDE ID
DR0095
ACDINA ID
D00032
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [10]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [10]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [12]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [13]
Cytochrome P450 2D6 (CYP2D6)
Main DME 		DECB0K3 CP2D6_HUMAN Substrate [12]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [14]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [15]
Mephenytoin 4-hydroxylase (CYP2C19)
Main DME 		DEGTFWK CP2CJ_HUMAN Substrate [16]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [17]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [18]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [19]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [20]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [8]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Drug Response [9]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [9]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Drug Response [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Depression
ICD Disease Classification 6A70-6A7Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serotonin transporter (SERT) DTT SLC6A4 8.76E-01 7.18E-05 6.19E-04
P-glycoprotein 1 (ABCB1) DTP P-GP 6.54E-01 1.95E-01 4.04E-01
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME UGT1A1 4.53E-01 4.14E-02 1.83E-01
Cytochrome P450 2E1 (CYP2E1) DME CYP2E1 9.45E-02 -1.86E-01 -9.83E-01
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 5.57E-01 -7.89E-02 -7.93E-01
Cytochrome P450 2B6 (CYP2B6) DME CYP2B6 4.32E-01 4.39E-02 4.30E-01
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 8.46E-01 -6.63E-03 -4.49E-02
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 9.57E-01 9.43E-03 1.29E-01
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 9.62E-01 2.57E-02 1.10E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 8.70E-01 2.98E-02 1.22E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 2.35E-01 2.78E-02 2.09E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.76E-01 1.26E-01 8.27E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Amitriptyline
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Trimipramine DM1SC8M Moderate Additive anticholinergic effects by the combination of Amitriptyline and Trimipramine. Depression [6A70-6A7Z] [21]
Imipramine DM2NUH3 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Imipramine. Depression [6A70-6A7Z] [21]
Fluoxetine DM3PD2C Major Decreased metabolism of Amitriptyline caused by Fluoxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [22]
Nortriptyline DM4KDYJ Moderate Additive anticholinergic effects by the combination of Amitriptyline and Nortriptyline. Depression [6A70-6A7Z] [21]
Vilazodone DM4LECQ Major Additive serotonergic effects by the combination of Amitriptyline and Vilazodone. Depression [6A70-6A7Z] [23]
Nefazodone DM4ZS8M Major Additive serotonergic effects by the combination of Amitriptyline and Nefazodone. Depression [6A70-6A7Z] [23]
Paroxetine DM5PVQE Major Decreased metabolism of Amitriptyline caused by Paroxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [24]
Selegiline DM6034S Major Additive serotonergic effects by the combination of Amitriptyline and Selegiline. Depression [6A70-6A7Z] [25]
Vortioxetine DM6F1PU Major Additive serotonergic effects by the combination of Amitriptyline and Vortioxetine. Depression [6A70-6A7Z] [23]
Duloxetine DM9BI7M Major Additive serotonergic effects by the combination of Amitriptyline and Duloxetine. Depression [6A70-6A7Z] [23]
Isocarboxazid DMAF1NB Major Additive serotonergic effects by the combination of Amitriptyline and Isocarboxazid. Depression [6A70-6A7Z] [25]
Milnacipran DMBFE74 Major Additive serotonergic effects by the combination of Amitriptyline and Milnacipran. Depression [6A70-6A7Z] [23]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Amitriptyline and Escitalopram. Depression [6A70-6A7Z] [26]
Tranylcypromine DMGB5RE Major Additive serotonergic effects by the combination of Amitriptyline and Tranylcypromine. Depression [6A70-6A7Z] [25]
Desvenlafaxine DMHD4PE Major Additive serotonergic effects by the combination of Amitriptyline and Desvenlafaxine. Depression [6A70-6A7Z] [23]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Amitriptyline and OPC-34712. Depression [6A70-6A7Z] [21]
Phenelzine DMHIDUE Major Additive serotonergic effects by the combination of Amitriptyline and Phenelzine. Depression [6A70-6A7Z] [25]
Clomipramine DMINRKW Moderate Additive anticholinergic effects by the combination of Amitriptyline and Clomipramine. Depression [6A70-6A7Z] [21]
Trazodone DMK1GBJ Major Additive serotonergic effects by the combination of Amitriptyline and Trazodone. Depression [6A70-6A7Z] [23]
Amoxapine DMKITQE Moderate Additive anticholinergic effects by the combination of Amitriptyline and Amoxapine. Depression [6A70-6A7Z] [21]
Mirtazapine DML53ZJ Major Additive serotonergic effects by the combination of Amitriptyline and Mirtazapine. Depression [6A70-6A7Z] [23]
Protriptyline DMNHTZI Moderate Additive anticholinergic effects by the combination of Amitriptyline and Protriptyline. Depression [6A70-6A7Z] [21]
Doxepin DMPI98T Moderate Additive anticholinergic effects by the combination of Amitriptyline and Doxepin. Depression [6A70-6A7Z] [21]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Amitriptyline and Maprotiline. Depression [6A70-6A7Z] [21]
⏷ Show the Full List of 24 DDI Information of This Drug
Coadministration of a Drug Treating the Disease Different from Amitriptyline (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Methylene blue DMJAPE7 Major Additive serotonergic effects by the combination of Amitriptyline and Methylene blue. Acquired methaemoglobinaemia [3A93] [25]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Ivosidenib. Acute myeloid leukaemia [2A60] [27]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Midostaurin. Acute myeloid leukaemia [2A60] [28]
Idarubicin DMM0XGL Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Idarubicin. Acute myeloid leukaemia [2A60] [28]
Daunorubicin DMQUSBT Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Daunorubicin. Acute myeloid leukaemia [2A60] [28]
Arn-509 DMT81LZ Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Arn-509. Acute myeloid leukaemia [2A60] [29]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Gilteritinib. Acute myeloid leukaemia [2A60] [30]
Oliceridine DM6MDCF Moderate Additive CNS depression effects by the combination of Amitriptyline and Oliceridine. Acute pain [MG31] [31]
Scopolamine DMOM8AL Moderate Additive anticholinergic effects by the combination of Amitriptyline and Scopolamine. Addictive disorder [6C50-6C5Z] [21]
Terfenadine DM4KLPT Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Terfenadine. Allergic/hypersensitivity disorder [4A80-4A8Z] [28]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Amitriptyline and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [32]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Amitriptyline and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [32]
Tripelennamine DMZBU15 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Tripelennamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [21]
Tacrine DM51FY6 Moderate Antagonize the effect of Amitriptyline when combined with Tacrine. Alzheimer disease [8A20] [33]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Amitriptyline and Memantine. Alzheimer disease [8A20] [21]
Galantamine DMEO794 Moderate Antagonize the effect of Amitriptyline when combined with Galantamine. Alzheimer disease [8A20] [33]
Rivastigmine DMG629M Moderate Antagonize the effect of Amitriptyline when combined with Rivastigmine. Alzheimer disease [8A20] [33]
Donepezil DMIYG7Z Moderate Antagonize the effect of Amitriptyline when combined with Donepezil. Alzheimer disease [8A20] [33]
Metronidazole DMTIVEN Minor Increased risk of prolong QT interval by the combination of Amitriptyline and Metronidazole. Amoebiasis [1A36] [34]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Amitriptyline and Ivabradine. Angina pectoris [BA40] [29]
Bepridil DM0RKS4 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Bepridil. Angina pectoris [BA40] [35]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Dronedarone. Angina pectoris [BA40] [28]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Amitriptyline and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [36]
Buspirone DMBS632 Major Additive serotonergic effects by the combination of Amitriptyline and Buspirone. Anxiety disorder [6B00-6B0Z] [23]
Hydroxyzine DMF8Y74 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [21]
Clobazam - Lundbeck DMW1OQ0 Moderate Decreased metabolism of Amitriptyline caused by Clobazam - Lundbeck mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [37]
Promazine DMZAL7W Moderate Increased plasma concentrations of Amitriptyline and Promazine due to competitive inhibition of the same metabolic pathway. Appearance/behaviour symptom [MB23] [38]
Cilostazol DMZMSCT Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Cilostazol. Arterial occlusive disease [BD40] [28]
Voriconazole DMAOL2S Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Voriconazole. Aspergillosis [1F20] [28]
Methylphenidate DM7SJD6 Moderate Decreased metabolism of Amitriptyline caused by Methylphenidate. Attention deficit hyperactivity disorder [6A05] [39]
Desipramine DMT2FDC Moderate Additive anticholinergic effects by the combination of Amitriptyline and Desipramine. Attention deficit hyperactivity disorder [6A05] [21]
Ofloxacin DM0VQN3 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Ofloxacin. Bacterial infection [1A00-1C4Z] [40]
Ciprofloxacin XR DM2NLS9 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Ciprofloxacin XR. Bacterial infection [1A00-1C4Z] [28]
Dalfopristin DM4LTKV Major Decreased metabolism of Amitriptyline caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [41]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Amitriptyline and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [28]
Sparfloxacin DMB4HCT Major Increased risk of prolong QT interval by the combination of Amitriptyline and Sparfloxacin. Bacterial infection [1A00-1C4Z] [40]
Linezolid DMGFPU2 Major Additive serotonergic effects by the combination of Amitriptyline and Linezolid. Bacterial infection [1A00-1C4Z] [42]
Gemifloxacin DMHT34O Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Gemifloxacin. Bacterial infection [1A00-1C4Z] [40]
Norfloxacin DMIZ6W2 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Norfloxacin. Bacterial infection [1A00-1C4Z] [40]
Levofloxacin DMS60RB Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Levofloxacin. Bacterial infection [1A00-1C4Z] [40]
Lomefloxacin DMVRH9C Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Lomefloxacin. Bacterial infection [1A00-1C4Z] [28]
Telithromycin DMZ4P3A Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Telithromycin. Bacterial infection [1A00-1C4Z] [28]
Retigabine DMGNYIH Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Retigabine. Behcet disease [4A62] [28]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Amitriptyline and Cariprazine. Bipolar disorder [6A60] [21]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Amitriptyline and Loperamide. Bowel habit change [ME05] [43]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Eribulin. Breast cancer [2C60-2C6Y] [28]
Lapatinib DM3BH1Y Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Lapatinib. Breast cancer [2C60-2C6Y] [28]
Alpelisib DMEXMYK Moderate Increased metabolism of Amitriptyline caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [44]
Tamoxifen DMLB0EZ Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Tamoxifen. Breast cancer [2C60-2C6Y] [28]
Toremifene DMQYUWG Major Increased risk of prolong QT interval by the combination of Amitriptyline and Toremifene. Breast cancer [2C60-2C6Y] [28]
Grepafloxacin DMGLX0T Major Increased risk of prolong QT interval by the combination of Amitriptyline and Grepafloxacin. Bronchitis [CA20] [40]
Sotalol DML60TN Major Increased risk of prolong QT interval by the combination of Amitriptyline and Sotalol. Cardiac arrhythmia [BC9Z] [28]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Amitriptyline when combined with Acetylcholine. Cataract [9B10] [45]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [46]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [47]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Amitriptyline and Tiotropium. Chronic obstructive pulmonary disease [CA22] [47]
Ipratropium DMFQ320 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Ipratropium. Chronic obstructive pulmonary disease [CA22] [47]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Amitriptyline and Revefenacin. Chronic obstructive pulmonary disease [CA22] [47]
Dihydrocodeine DMB0FWL Moderate Additive serotonergic effects by the combination of Amitriptyline and Dihydrocodeine. Chronic pain [MG30] [31]
Levomilnacipran DMV26S8 Major Additive serotonergic effects by the combination of Amitriptyline and Levomilnacipran. Chronic pain [MG30] [23]
Oxaliplatin DMQNWRD Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Oxaliplatin. Colorectal cancer [2B91] [28]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Amitriptyline and Olopatadine. Conjunctiva disorder [9A60] [48]
Mestranol DMG3F94 Minor Decreased metabolism of Amitriptyline caused by Mestranol. Contraceptive management [QA21] [49]
Halothane DM80OZ5 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Halothane. Corneal disease [9A76-9A78] [28]
Alfentanil DMVO0UB Moderate Additive serotonergic effects by the combination of Amitriptyline and Alfentanil. Corneal disease [9A76-9A78] [31]
Remifentanil DMZTXCH Moderate Additive CNS depression effects by the combination of Amitriptyline and Remifentanil. Corneal disease [9A76-9A78] [31]
Probucol DMVZQ2M Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Probucol. Coronary atherosclerosis [BA80] [28]
Methadone DMTW6IU Major Increased risk of prolong QT interval by the combination of Amitriptyline and Methadone. Cough [MD12] [28]
Clofazimine DMEBOFW Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Clofazimine. Crohn disease [DD70] [50]
Mifepristone DMGZQEF Major Increased risk of prolong QT interval by the combination of Amitriptyline and Mifepristone. Cushing syndrome [5A70] [28]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Osilodrostat. Cushing syndrome [5A70] [29]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Amitriptyline and Ethanol. Cystitis [GC00] [51]
Hyoscyamine DM804UR Moderate Additive anticholinergic effects by the combination of Amitriptyline and Hyoscyamine. Digestive system disease [DE2Z] [21]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Amitriptyline and Mepenzolate. Digestive system disease [DE2Z] [21]
5-hydroxy-L-tryptophan DMDWZGJ Major Additive serotonergic effects by the combination of Amitriptyline and 5-hydroxy-L-tryptophan. Discovery agent [N.A.] [52]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Amitriptyline and Oxybutynine. Discovery agent [N.A.] [21]
Tetrabenazine DMYWQ0O Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [28]
Meclizine DMS7T13 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Meclizine. Dizziness and giddiness [MB48] [21]
Trihexyphenidyl DMB19L8 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Trihexyphenidyl. Dystonic disorder [8A02] [21]
Deutetrabenazine DMUPFLI Moderate Additive CNS depression effects by the combination of Amitriptyline and Deutetrabenazine. Dystonic disorder [8A02] [53]
Fenfluramine DM0762O Moderate Additive serotonergic effects by the combination of Amitriptyline and Fenfluramine. Epilepsy/seizure [8A61-8A6Z] [54]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Amitriptyline and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [55]
Oxcarbazepine DM5PU6O Moderate Decreased metabolism of Amitriptyline caused by Oxcarbazepine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [34]
Fosphenytoin DMOX3LB Moderate Decreased metabolism of Amitriptyline caused by Fosphenytoin mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [56]
Carbamazepine DMZOLBI Moderate Antagonize the effect of Amitriptyline when combined with Carbamazepine. Epilepsy/seizure [8A61-8A6Z] [57]
Diphenhydramine DMKQTBA Moderate Additive anticholinergic effects by the combination of Amitriptyline and Diphenhydramine. Episodic vestibular syndrome [AB31] [21]
Solifenacin DMG592Q Moderate Additive anticholinergic effects by the combination of Amitriptyline and Solifenacin. Functional bladder disorder [GC50] [21]
Mirabegron DMS1GYT Moderate Decreased metabolism of Amitriptyline caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [58]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Tolterodine. Functional bladder disorder [GC50] [21]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Amitriptyline caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [59]
Itraconazole DMCR1MV Moderate Decreased metabolism of Amitriptyline caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [60]
Pentamidine DMHZJCG Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Pentamidine. Fungal infection [1F29-1F2F] [28]
Terbinafine DMI6HUW Moderate Decreased metabolism of Amitriptyline caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [61]
Miconazole DMPMYE8 Moderate Decreased metabolism of Amitriptyline caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [60]
Propantheline DM2EN6G Moderate Additive anticholinergic effects by the combination of Amitriptyline and Propantheline. Gastric ulcer [DA60] [21]
Cimetidine DMH61ZB Moderate Decreased metabolism of Amitriptyline caused by Cimetidine mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [62]
Cisapride DMY7PED Major Increased risk of prolong QT interval by the combination of Amitriptyline and Cisapride. Gastro-oesophageal reflux disease [DA22] [28]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Sunitinib. Gastrointestinal stromal tumour [2B5B] [28]
Acetazolamide DM1AF5U Minor as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Amitriptyline caused by Acetazolamide mediated altered urine pH. Glaucoma [9C61] [63]
Isoflurophate DMBSK7X Moderate Antagonize the effect of Amitriptyline when combined with Isoflurophate. Glaucoma [9C61] [45]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Amitriptyline and Brimonidine. Glaucoma [9C61] [64]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Amitriptyline when combined with Pilocarpine. Glaucoma [9C61] [45]
Carvedilol DMHTEAO Moderate Increased plasma concentrations of Amitriptyline and Carvedilol due to competitive inhibition of the same metabolic pathway. Heart failure [BD10-BD1Z] [56]
Procarbazine DMIK367 Major Additive serotonergic effects by the combination of Amitriptyline and Procarbazine. Hodgkin lymphoma [2B30] [25]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Amitriptyline caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [65]
Fostemsavir DM50ILT Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [66]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Amitriptyline caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [67]
Efavirenz DMC0GSJ Major Increased risk of prolong QT interval by the combination of Amitriptyline and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [68]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Amitriptyline and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [69]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [28]
Amprenavir DMLMXE0 Moderate Decreased metabolism of Amitriptyline caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [65]
Atazanavir DMSYRBX Moderate Decreased metabolism of Amitriptyline caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [65]
Ritonavir DMU764S Moderate Decreased metabolism of Amitriptyline caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [70]
Cinacalcet DMCX0K3 Moderate Decreased metabolism of Amitriptyline caused by Cinacalcet mediated inhibition of CYP450 enzyme. Hyper-parathyroidism [5A51] [34]
Verapamil DMA7PEW Moderate Decreased metabolism of Amitriptyline caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [71]
Labetalol DMK8U72 Moderate Increased plasma concentrations of Amitriptyline and Labetalol due to competitive inhibition of the same metabolic pathway. Hypertension [BA00-BA04] [56]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Amitriptyline and Belladonna. Infectious gastroenteritis/colitis [1A40] [21]
Propiomazine DMKY8V1 Moderate Increased plasma concentrations of Amitriptyline and Propiomazine due to competitive inhibition of the same metabolic pathway. Insomnia [7A00-7A0Z] [38]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Amitriptyline and ITI-007. Insomnia [7A00-7A0Z] [21]
Polyethylene glycol DM4I1JP Moderate Increased risk of ventricular arrhythmias by the combination of Amitriptyline and Polyethylene glycol. Irritable bowel syndrome [DD91] [28]
Clidinium DMUMQZ0 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Clidinium. Irritable bowel syndrome [DD91] [21]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Amitriptyline and Dicyclomine. Irritable bowel syndrome [DD91] [21]
Physostigmine DM2N0TO Moderate Antagonize the effect of Amitriptyline when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [33]
Glycerol phenylbutyrate DMDGRQO Moderate Decreased metabolism of Amitriptyline caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme. Liver disease [DB90-DB9Z] [29]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Amitriptyline and Ceritinib. Lung cancer [2C25] [28]
PF-06463922 DMKM7EW Moderate Increased metabolism of Amitriptyline caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [72]
Dacomitinib DMOH8VY Moderate Decreased metabolism of Amitriptyline caused by Dacomitinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [73]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Amitriptyline and Osimertinib. Lung cancer [2C25] [74]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Amitriptyline and Halofantrine. Malaria [1F40-1F45] [75]
Chloroquine DMSI5CB Major Increased risk of prolong QT interval by the combination of Amitriptyline and Chloroquine. Malaria [1F40-1F45] [76]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Amitriptyline and Hydroxychloroquine. Malaria [1F40-1F45] [76]
Quinine DMSWYF5 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Quinine. Malaria [1F40-1F45] [28]
Primaquine DMWQ16I Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Primaquine. Malaria [1F40-1F45] [28]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [29]
IPI-145 DMWA24P Moderate Decreased metabolism of Amitriptyline caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [77]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Arsenic trioxide. Mature B-cell lymphoma [2A85] [78]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Vemurafenib. Melanoma [2C30] [28]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and LGX818. Melanoma [2C30] [79]
Ethinyl estradiol DMODJ40 Minor Decreased metabolism of Amitriptyline caused by Ethinyl estradiol. Menopausal disorder [GA30] [49]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Amitriptyline and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [80]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Amitriptyline and Flibanserin. Mood disorder [6A60-6E23] [81]
Doxylamine DMKOXFE Moderate Additive anticholinergic effects by the combination of Amitriptyline and Doxylamine. Morning sickness disorder [SC00] [21]
Riluzole DMECBWN Minor Decreased metabolism of Amitriptyline caused by Riluzole mediated inhibition of CYP450 enzyme. Motor neuron disease [8B60] [82]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Amitriptyline and Panobinostat. Multiple myeloma [2A83] [83]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Amitriptyline and Thalidomide. Multiple myeloma [2A83] [84]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Amitriptyline and Siponimod. Multiple sclerosis [8A40] [34]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Amitriptyline and Fingolimod. Multiple sclerosis [8A40] [28]
Ozanimod DMT6AM2 Major Additive serotonergic effects by the combination of Amitriptyline and Ozanimod. Multiple sclerosis [8A40] [85]
Romidepsin DMT5GNL Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Romidepsin. Mycosis fungoides [2B01] [28]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Amitriptyline caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [29]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Amitriptyline and Nilotinib. Myeloproliferative neoplasm [2A20] [28]
Imatinib DM7RJXL Moderate Decreased metabolism of Amitriptyline caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [86]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Dasatinib. Myeloproliferative neoplasm [2A20] [87]
Modafinil DMYILBE Moderate Decreased metabolism of Amitriptyline caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [34]
Phenindamine DMDTC7R Moderate Additive anticholinergic effects by the combination of Amitriptyline and Phenindamine. Nasopharyngitis [CA00] [21]
Droperidol DM0DXA8 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Droperidol. Nausea/vomiting [MD90] [28]
Prochlorperazine DM53SRA Moderate Increased plasma concentrations of Amitriptyline and Prochlorperazine due to competitive inhibition of the same metabolic pathway. Nausea/vomiting [MD90] [38]
Promethazine DM6I5GR Moderate Increased plasma concentrations of Amitriptyline and Promethazine due to competitive inhibition of the same metabolic pathway. Nausea/vomiting [MD90] [38]
Rolapitant DM8XP26 Moderate Decreased metabolism of Amitriptyline caused by Rolapitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [88]
Cyclizine DM9G7BS Moderate Additive anticholinergic effects by the combination of Amitriptyline and Cyclizine. Nausea/vomiting [MD90] [21]
Palonosetron DMBHMOX Major Increased risk of prolong QT interval by the combination of Amitriptyline and Palonosetron. Nausea/vomiting [MD90] [28]
Granisetron DMIUW25 Major Additive serotonergic effects by the combination of Amitriptyline and Granisetron. Nausea/vomiting [MD90] [28]
Ondansetron DMOTQ1I Major Increased risk of prolong QT interval by the combination of Amitriptyline and Ondansetron. Nausea/vomiting [MD90] [28]
Thiethylperazine DMU3IET Moderate Increased plasma concentrations of Amitriptyline and Thiethylperazine due to competitive inhibition of the same metabolic pathway. Nausea/vomiting [MD90] [38]
Bupropion DM5PCS7 Major Decreased metabolism of Amitriptyline caused by Bupropion mediated inhibition of CYP450 enzyme. Nicotine use disorder [6C4A] [28]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Entrectinib. Non-small cell lung cancer [2C25] [34]
Sibutramine DMFJTDI Major Additive serotonergic effects by the combination of Amitriptyline and Sibutramine. Obesity [5B80-5B81] [89]
Lorcaserin DMG6OYJ Major Additive serotonergic effects by the combination of Amitriptyline and Lorcaserin. Obesity [5B80-5B81] [90]
Dexfenfluramine DMJ7YDS Major Additive serotonergic effects by the combination of Amitriptyline and Dexfenfluramine. Obesity [5B80-5B81] [23]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Levomethadyl Acetate. Opioid use disorder [6C43] [29]
Lofexidine DM1WXA6 Moderate Additive CNS depression effects by the combination of Amitriptyline and Lofexidine. Opioid use disorder [6C43] [29]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Amitriptyline and Apraclonidine. Optic nerve disorder [9C40] [91]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Rucaparib. Ovarian cancer [2C73] [28]
Altretamine DMKLAYG Moderate Additive hypotensive effects by the combination of Amitriptyline and Altretamine. Ovarian cancer [2C73] [92]
Pentazocine DM1XBHS Moderate Additive CNS depression effects by the combination of Amitriptyline and Pentazocine. Pain [MG30-MG3Z] [31]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Amitriptyline and Dextropropoxyphene. Pain [MG30-MG3Z] [93]
Butorphanol DM5KYPJ Moderate Additive CNS depression effects by the combination of Amitriptyline and Butorphanol. Pain [MG30-MG3Z] [31]
Oxymorphone DM65AGJ Moderate Additive CNS depression effects by the combination of Amitriptyline and Oxymorphone. Pain [MG30-MG3Z] [31]
Levorphanol DMGS80V Moderate Additive CNS depression effects by the combination of Amitriptyline and Levorphanol. Pain [MG30-MG3Z] [31]
Hydromorphone DMHP21E Moderate Additive CNS depression effects by the combination of Amitriptyline and Hydromorphone. Pain [MG30-MG3Z] [31]
Dezocine DMJDB0Y Moderate Additive CNS depression effects by the combination of Amitriptyline and Dezocine. Pain [MG30-MG3Z] [31]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Amitriptyline and Flavoxate. Pain [MG30-MG3Z] [21]
Nalbuphine DMOSQGU Moderate Additive CNS depression effects by the combination of Amitriptyline and Nalbuphine. Pain [MG30-MG3Z] [31]
Buprenorphine DMPRI8G Moderate Additive CNS depression effects by the combination of Amitriptyline and Buprenorphine. Pain [MG30-MG3Z] [31]
Hydrocodone DMQ2JO5 Moderate Additive CNS depression effects by the combination of Amitriptyline and Hydrocodone. Pain [MG30-MG3Z] [31]
Meperidine DMX4GND Major Additive serotonergic effects by the combination of Amitriptyline and Meperidine. Pain [MG30-MG3Z] [23]
Oxycodone DMXLKHV Moderate Additive serotonergic effects by the combination of Amitriptyline and Oxycodone. Pain [MG30-MG3Z] [31]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Triclabendazole. Parasitic worm infestation [1F90] [28]
Safinamide DM0YWJC Major Additive serotonergic effects by the combination of Amitriptyline and Safinamide. Parkinsonism [8A00] [85]
Rasagiline DM3WKQ4 Major Additive serotonergic effects by the combination of Amitriptyline and Rasagiline. Parkinsonism [8A00] [25]
Biperiden DME78OA Moderate Additive anticholinergic effects by the combination of Amitriptyline and Biperiden. Parkinsonism [8A00] [21]
Procyclidine DMHFJDT Moderate Additive anticholinergic effects by the combination of Amitriptyline and Procyclidine. Parkinsonism [8A00] [21]
Levodopa DMN3E57 Minor Altered absorption of Amitriptyline due to GI dynamics variation caused by Levodopa. Parkinsonism [8A00] [94]
Pimavanserin DMR7IVC Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Pimavanserin. Parkinsonism [8A00] [95]
Orphenadrine DMW542E Moderate Additive anticholinergic effects by the combination of Amitriptyline and Orphenadrine. Parkinsonism [8A00] [21]
Apomorphine DMX38HQ Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Apomorphine. Parkinsonism [8A00] [28]
Abametapir DM2RX0I Moderate Decreased metabolism of Amitriptyline caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [96]
Lindane DMB8CNL Moderate Increased risk of lowers seizure threshold by the combination of Amitriptyline and Lindane. Pediculosis [1G00] [97]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Amitriptyline and Methylscopolamine. Peptic ulcer [DA61] [21]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Famotidine. Peptic ulcer [DA61] [34]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Amitriptyline and Macimorelin. Pituitary gland disorder [5A60-5A61] [98]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Lefamulin. Pneumonia [CA40] [99]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Degarelix. Prostate cancer [2C82] [29]
ABIRATERONE DM8V75C Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and ABIRATERONE. Prostate cancer [2C82] [29]
Nilutamide DMFN07X Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Nilutamide. Prostate cancer [2C82] [29]
Enzalutamide DMGL19D Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Enzalutamide. Prostate cancer [2C82] [29]
Flutamide DMK0O7U Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Flutamide. Prostate cancer [2C82] [29]
Bicalutamide DMZMSPF Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Bicalutamide. Prostate cancer [2C82] [29]
Levomepromazine DMIKFEL Moderate Increased plasma concentrations of Amitriptyline and Levomepromazine due to competitive inhibition of the same metabolic pathway. Psychotic disorder [6A20-6A25] [38]
Fluphenazine DMIT8LX Moderate Increased plasma concentrations of Amitriptyline and Fluphenazine due to competitive inhibition of the same metabolic pathway. Psychotic disorder [6A20-6A25] [38]
Triflupromazine DMKFQJP Moderate Increased plasma concentrations of Amitriptyline and Triflupromazine due to competitive inhibition of the same metabolic pathway. Psychotic disorder [6A20-6A25] [38]
Sorafenib DMS8IFC Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Sorafenib. Renal cell carcinoma [2C90] [28]
Gatifloxacin DMSL679 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Gatifloxacin. Respiratory infection [CA07-CA4Z] [100]
Celecoxib DM6LOQU Moderate Decreased metabolism of Amitriptyline caused by Celecoxib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [101]
Cyproheptadine DM92AH3 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Cyproheptadine. Rheumatoid arthritis [FA20] [21]
Quetiapine DM1N62C Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Quetiapine. Schizophrenia [6A20] [28]
Mesoridazine DM2ZGAN Major Increased risk of prolong QT interval by the combination of Amitriptyline and Mesoridazine. Schizophrenia [6A20] [28]
Thioridazine DM35M8J Major Increased risk of prolong QT interval by the combination of Amitriptyline and Thioridazine. Schizophrenia [6A20] [102]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Amitriptyline and Aripiprazole. Schizophrenia [6A20] [21]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Amitriptyline and Iloperidone. Schizophrenia [6A20] [28]
Paliperidone DM7NPJS Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Paliperidone. Schizophrenia [6A20] [28]
Loxapine DM8AI9U Moderate Additive anticholinergic effects by the combination of Amitriptyline and Loxapine. Schizophrenia [6A20] [21]
Haloperidol DM96SE0 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Haloperidol. Schizophrenia [6A20] [103]
Perphenazine DMA4MRX Moderate Increased plasma concentrations of Amitriptyline and Perphenazine due to competitive inhibition of the same metabolic pathway. Schizophrenia [6A20] [38]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Amitriptyline and Molindone. Schizophrenia [6A20] [21]
Chlorpromazine DMBGZI3 Moderate Increased plasma concentrations of Amitriptyline and Chlorpromazine due to competitive inhibition of the same metabolic pathway. Schizophrenia [6A20] [38]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Thiothixene. Schizophrenia [6A20] [21]
Trifluoperazine DMKBYWI Moderate Increased plasma concentrations of Amitriptyline and Trifluoperazine due to competitive inhibition of the same metabolic pathway. Schizophrenia [6A20] [38]
Risperidone DMN6DXL Moderate Additive anticholinergic effects by the combination of Amitriptyline and Risperidone. Schizophrenia [6A20] [21]
Olanzapine DMPFN6Y Moderate Additive anticholinergic effects by the combination of Amitriptyline and Olanzapine. Schizophrenia [6A20] [21]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Amitriptyline and Amisulpride. Schizophrenia [6A20] [104]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Asenapine. Schizophrenia [6A20] [28]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Amitriptyline and Pimozide. Schizophrenia [6A20] [29]
Sufentanil DMU7YEL Moderate Additive CNS depression effects by the combination of Amitriptyline and Sufentanil. Sensation disturbance [MB40] [31]
Vardenafil DMTBGW8 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Vardenafil. Sexual dysfunction [HA00-HA01] [28]
Armodafinil DMGB035 Moderate Decreased metabolism of Amitriptyline caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [34]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Amitriptyline and LEE011. Solid tumour/cancer [2A00-2F9Z] [28]
Epirubicin DMPDW6T Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Epirubicin. Solid tumour/cancer [2A00-2F9Z] [28]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Amitriptyline and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [28]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [29]
Doxorubicin DMVP5YE Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [28]
Telavancin DM58VQX Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [28]
Adenosine DMM2NSK Moderate Increased risk of ventricular arrhythmias by the combination of Amitriptyline and Adenosine. Supraventricular tachyarrhythmia [BC81] [28]
Fostamatinib DM6AUHV Moderate Decreased clearance of Amitriptyline due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [105]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Lenvatinib. Thyroid cancer [2D10] [28]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Cabozantinib. Thyroid cancer [2D10] [29]
Papaverine DMCA9QP Major Increased risk of prolong QT interval by the combination of Amitriptyline and Papaverine. Tonus and reflex abnormality [MB47] [106]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Amitriptyline and Tizanidine. Tonus and reflex abnormality [MB47] [107]
Tacrolimus DMZ7XNQ Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Tacrolimus. Transplant rejection [NE84] [28]
Atropine DMEN6X7 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Atropine. Unspecific substance harmful effect [NE6Z] [21]
Astemizole DM2HN6Q Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Astemizole. Vasomotor/allergic rhinitis [CA08] [28]
Triprolidine DM7SWIA Moderate Additive anticholinergic effects by the combination of Amitriptyline and Triprolidine. Vasomotor/allergic rhinitis [CA08] [21]
Methdilazine DMAUHQX Moderate Increased plasma concentrations of Amitriptyline and Methdilazine due to competitive inhibition of the same metabolic pathway. Vasomotor/allergic rhinitis [CA08] [38]
Carbinoxamine DMCT31R Moderate Additive anticholinergic effects by the combination of Amitriptyline and Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [21]
Trimeprazine DMEMV9D Moderate Increased plasma concentrations of Amitriptyline and Trimeprazine due to competitive inhibition of the same metabolic pathway. Vasomotor/allergic rhinitis [CA08] [108]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Amitriptyline and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [21]
Dexbrompheniramine DMKVWGE Moderate Additive anticholinergic effects by the combination of Amitriptyline and Dexbrompheniramine. Vasomotor/allergic rhinitis [CA08] [21]
Cetirizine DMOMP9U Moderate Additive CNS depression effects by the combination of Amitriptyline and Cetirizine. Vasomotor/allergic rhinitis [CA08] [109]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Amitriptyline and Acrivastine. Vasomotor/allergic rhinitis [CA08] [21]
Azatadine DMZ80SB Moderate Additive anticholinergic effects by the combination of Amitriptyline and Azatadine. Vasomotor/allergic rhinitis [CA08] [21]
Procainamide DMNMXR8 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Procainamide. Ventricular tachyarrhythmia [BC71] [28]
Propafenone DMPIBJK Moderate Decreased metabolism of Amitriptyline caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [110]
Flecainide DMSQDLE Moderate Increased risk of prolong QT interval by the combination of Amitriptyline and Flecainide. Ventricular tachyarrhythmia [BC71] [110]
Amiodarone DMUTEX3 Major Increased risk of prolong QT interval by the combination of Amitriptyline and Amiodarone. Ventricular tachyarrhythmia [BC71] [28]
⏷ Show the Full List of 264 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
D&C red no. 27 E00381 83511 Colorant
D&C red no. 30 E00456 3000709 Colorant
D&C red no. 33 E00261 19116 Colorant
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Hydrazine yellow E00409 164825 Colorant
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Calcium sulfate anhydrous E00303 24497 Desiccant; Diluent
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Lithol rubin BCA E00607 135423095 Colorant
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 400 E00653 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 26 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Amitriptyline 10 mg tablet 10 mg Oral Tablet Oral
Amitriptyline 100 mg tablet 100 mg Oral Tablet Oral
Amitriptyline 150 mg tablet 150 mg Oral Tablet Oral
Amitriptyline 25 mg tablet 25 mg Oral Tablet Oral
Amitriptyline 50 mg tablet 50 mg Oral Tablet Oral
Amitriptyline 75 mg tablet 75 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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