Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHJEZS)

Drug Name

CR-3294 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diarrhea	ME05.1	Phase 2	[1]

Cross-matching ID

PubChem CID: 53474619
TTD Drug ID: DMHJEZS

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

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Drug(s) Targeting Nitric-oxide synthase inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
SD-6010	DM9DEYL	Osteoarthritis	FA00-FA05	Phase 3	[5]
MPL-S	DMNDCFY	Endotoxic shock	1G41	Phase 3	[6]
Pimagedine HCl	DMPWH30	Diabetic kidney disease	GB61.Z	Phase 2/3	[7]
GW274150	DMZMCB1	Asthma	CA23	Phase 2	[8]
BXT-51072	DMD8GNB	Cardiovascular disease	BA00-BE2Z	Phase 2	[9]
HP-228	DMNZ35F	Postoperative pain	MG30-MG3Z	Phase 2	[10]
KD-7040	DME1WV2	Pain	MG30-MG3Z	Phase 2	[11]
LT-1951	DM5N04G	Coronary artery disease	BA80	Phase 1/2	[12]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[13]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Indomethacin	DMSC4A7	Bursitis		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[21]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[22]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[23]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[36]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[41]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[42]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Gene/Protein Processing	[3]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Gene/Protein Processing	[3]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[3]

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References

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