Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHLEGT)

Drug Name

ON-123 Drug Info

Synonyms

ON-1231320; ON-123 series (cancer); Sulfonyl pyridopyrimidines (cancer), Onconova; ON-123 series (cancer), Onconova; Plk-2 inhibitors (cancer), Onconova; Polo-like kinase 2 inhibitors (cancer), Onconova

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMHLEGT

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Polo-like kinase 2 (PLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8598172, 1	DM0YD3Z	N. A.	N. A.	Patented	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polo-like kinase 2 (PLK2)	TT976FS	PLK2_HUMAN	Inhibitor	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2169).
2	Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors. US8598172.