Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHWITR)

Drug Name

1-(isoquinolin-5-yl)-3-(4-morpholinobenzyl)urea Drug Info

Synonyms

Isoquinoline Analogue, 35; CHEMBL231105; SCHEMBL4023640; BDBM20341; LAJBRLBYOVKUOY-UHFFFAOYSA-N; N-5-isoquinolinyl-N'-[4-(4-morpholinyl)benzyl]urea; N-isoquinolin-5-yl-N'-[(4-morpholin-4-ylphenyl)methyl]urea

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10248092
TTD Drug ID: DMHWITR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Transient receptor potential cation channel V1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[2]
CNTX-4975	DMB4JPG	Knee osteoarthritis	FA01	Phase 3	[3]
XEN-D0501	DMG7PDY	Overactive bladder	GC50.0	Phase 2	[4]
Resiniferatoxin	DMP62L5	Neuropathic pain	8E43.0	Phase 2	[5]
PAC-14028	DM3816P	Atopic dermatitis	EA80	Phase 2	[6]
GRC-15300	DMWXJSZ	Pain	MG30-MG3Z	Phase 2	[7]
DWP-05195	DMQKU2F	Neuropathic pain	8E43.0	Phase 2	[8]
SB-705498	DMRYHWI	Rhinitis	FA20	Phase 2	[9]
GRC-6211	DMZ0D3V	Asthma	CA23	Phase 1	[10]
ABT-102	DMJFWPR	Chronic pain	MG30	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Inhibitor	[1]

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References

1	In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 ... J Med Chem. 2007 Jul 26;50(15):3651-60.
2	Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31.
5	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
6	Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.
7	The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 2010 November 1; 120(11): 3753-3759.
8	TRPV1 Antagonists as Analgesic Agents. The Open Pain Journal, 2013, 6, (Suppl 1: M11), 108-118 .
9	Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6.
10	GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86.