Details of the Drug-Related molecule(s) Interaction Atlas

2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid Drug Info

24967-27-9; Neu5Ac2en; 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid; N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid; 2-deoxy-2,3-dehydro-n-acetyl-neuraminic acid; 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid; N-Acetyl-2,3-didehydro-2-deoxyneuraminic acid; EINECS 246-550-7; CHEMBL96712; CHEBI:28062; C11H17NO8; (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; 1,3-Dehydro-2-deoxy-N-acetylneuraminic acid

Cross-matching ID

PubChem CID

65309

ChEBI ID

CHEBI:28062

CAS Number

CAS 24967-27-9

TTD Drug ID

DMIAM5L

General Information of Drug (ID: DMIAM5L)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[2]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[2]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[3]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[1]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[3]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[4]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[1]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[5]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[6]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
3	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
4	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
5	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
6	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.