Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMID3F7)

Drug Name

NNC55-0396 Drug Info

Synonyms

NNC 55-0396

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Cation channel sperm-associated protein 3 (CatSper3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF1alpha	DMUPWQT	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cation channel sperm-associated protein 1 (CatSper1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF1alpha	DMUPWQT	Discovery agent	N.A.	Investigative	[3]
HC-056456	DMOG1Q4	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Cation channel sperm-associated protein (CatSper)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF1alpha	DMUPWQT	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cation channel sperm-associated protein 2 (CatSper2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PGF1alpha	DMUPWQT	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cation channel sperm-associated protein (CatSper)	TTWOCZI	NOUNIPROTAC	Blocker (channel blocker)	[2]
Cation channel sperm-associated protein 1 (CatSper1)	TT5CISB	CTSR1_HUMAN	Blocker (channel blocker)	[2]
Cation channel sperm-associated protein 2 (CatSper2)	TTOEGC4	CTSR2_HUMAN	Blocker (channel blocker)	[2]
Cation channel sperm-associated protein 3 (CatSper3)	TTP52ZV	CTSR3_HUMAN	Blocker (channel blocker)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4269).
2	The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6.
3	Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91.
4	Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844.