Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIMD0T)

Drug Name

ARI-3099 Drug Info

Synonyms

compound 6 [PMID: 23594271]; compound 226 [PMID: 24997602]; Py(D)AlaboroPro

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Prolyl endopeptidase FAP (FAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talabostat	DM1IZ5D	Constitutional neutropenia	4B00.0	Phase 3	[3]
BIBH 1	DMHYZEK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
Sibrotuzumab	DMT4UC1	Metastatic colorectal cancer	2B91	Phase 2	[4]
NG-641	DMITVHM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
AMG 506	DMG64PE	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
RG7461	DM5OTGR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
PT630	DM9SY8E	Colon cancer	2B90.Z	Preclinical	[8]
FAP5-DM1	DMYFVZ3	Solid tumour/cancer	2A00-2F9Z	Preclinical	[9]
MIP-1231	DM2IGD1	Solid tumour/cancer	2A00-2F9Z	Investigative	[10]
FE-999040	DM3UCWM	Solid tumour/cancer	2A00-2F9Z	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acylamino-acid-releasing enzyme (APEH)	TTYWEDQ	ACPH_HUMAN	Inhibitor	[1]
Prolyl endopeptidase FAP (FAP)	TTGPQ0F	SEPR_HUMAN	Inhibitor	[2]

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References

1	A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63.
2	Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77.
3	Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther. 2007 Nov;6(11):1691-9.
4	A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 2003 May;9(5):1639-47.
5	Clinical pipeline report, company report or official report of PsiOxus Therapeutics.
6	Clinical pipeline report, company report or official report of Amgen.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 2009 Dec;119(12):3613-25.
9	Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res. 2008 Jul 15;14(14):4584-92.
10	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2365).