Details of the Drug

General Information of Drug (ID: DM9SY8E)

Drug Name
PT630
Indication
Disease Entry ICD 11 Status REF
Colon cancer 2B90.Z Preclinical [1]
Lung cancer 2C25.0 Preclinical [1]
Drug Type
Peptide
Cross-matching ID
PubChem CID
11673176
TTD ID
D7K0GP
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Inhibitor [1]
Prolyl endopeptidase FAP (FAP) TTGPQ0F SEPR_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Colon cancer
ICD Disease Classification 2B90.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Prolyl endopeptidase FAP (FAP) DTT FAP 2.01E-01 0.07 0.84
Dipeptidyl peptidase 4 (DPP-4) DTT DPP4 9.54E-01 -0.27 -1.85
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 2009 Dec;119(12):3613-25.