Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIVGOR)

• Drug Name: sarcosine Drug Info
• Synonyms: sarcosine; 107-97-1; N-methylglycine; Sarcosinic acid; Methylglycine; Glycine, N-methyl-; Methylaminoacetic acid; 2-(methylamino)acetic acid; N-Methylaminoacetic acid; Sarcosin; (Methylamino)acetic acid; (Methylamino)ethanoic acid; Sargosine hydrochloride; N-Methyl glycine; Acetic acid, (methylamino)-; Cocoylsarcosine; Polysarcosine; N-methyl-Glycine; H-Sar-OH; UNII-Z711V88R5F; BRN 1699442; Sarcosine, 98%; AI3-15410; Methylamino-Acetic Acid; EINECS 203-538-6; SAR; CHEMBL304383; CHEBI:15611; FSYKKLYZXJSNPZ-UHFFFAOYSA-N; Z711V88R5F

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1088
  ChEBI ID: CHEBI:15611
  CAS Number: CAS 107-97-1
  TTD Drug ID: DMIVGOR
  VARIDT Drug ID: DR00326

Molecule-Related Drug Atlas

Drug(s) Transported By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[3]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)	DT2CFQ5	SC6A9_HUMAN	Substrate	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4713).
• [2] Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32.
• [3] Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268.