Details of the Drug

General Information of Drug (ID: DMIVGOR)

Drug Name
sarcosine
Synonyms
sarcosine; 107-97-1; N-methylglycine; Sarcosinic acid; Methylglycine; Glycine, N-methyl-; Methylaminoacetic acid; 2-(methylamino)acetic acid; N-Methylaminoacetic acid; Sarcosin; (Methylamino)acetic acid; (Methylamino)ethanoic acid; Sargosine hydrochloride; N-Methyl glycine; Acetic acid, (methylamino)-; Cocoylsarcosine; Polysarcosine; N-methyl-Glycine; H-Sar-OH; UNII-Z711V88R5F; BRN 1699442; Sarcosine, 98%; AI3-15410; Methylamino-Acetic Acid; EINECS 203-538-6; SAR; CHEMBL304383; CHEBI:15611; FSYKKLYZXJSNPZ-UHFFFAOYSA-N; Z711V88R5F
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 89.09
Logarithm of the Partition Coefficient (xlogp) -2.8
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C3H7NO2
IUPAC Name
2-(methylamino)acetic acid
Canonical SMILES
CNCC(=O)O
InChI
InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChIKey
FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
1088
ChEBI ID
CHEMBL15611
CAS Number
107-97-1
UNII
Z711V88R5F
DrugBank ID
DB12519
TTD ID
D0YF9S
VARIDT ID
DR00326
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) DT2CFQ5 SC6A9_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4713).
2 Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32.