Details of the Drug

General Information of Drug (ID: DMIVGOR)

Drug Name

sarcosine

Synonyms

sarcosine; 107-97-1; N-methylglycine; Sarcosinic acid; Methylglycine; Glycine, N-methyl-; Methylaminoacetic acid; 2-(methylamino)acetic acid; N-Methylaminoacetic acid; Sarcosin; (Methylamino)acetic acid; (Methylamino)ethanoic acid; Sargosine hydrochloride; N-Methyl glycine; Acetic acid, (methylamino)-; Cocoylsarcosine; Polysarcosine; N-methyl-Glycine; H-Sar-OH; UNII-Z711V88R5F; BRN 1699442; Sarcosine, 98%; AI3-15410; Methylamino-Acetic Acid; EINECS 203-538-6; SAR; CHEMBL304383; CHEBI:15611; FSYKKLYZXJSNPZ-UHFFFAOYSA-N; Z711V88R5F

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

89.09

Logarithm of the Partition Coefficient (xlogp)

-2.8

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C3H7NO2
IUPAC Name: 2-(methylamino)acetic acid
Canonical SMILES: CNCC(=O)O
InChI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChIKey: FSYKKLYZXJSNPZ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 1088
ChEBI ID: CHEBI:15611
CAS Number: 107-97-1
UNII: Z711V88R5F
DrugBank ID: DB12519
TTD ID: D0YF9S
VARIDT ID: DR00326

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)	DT2CFQ5	SC6A9_HUMAN	Substrate	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4713).
2	Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32.