Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ7IKW)

Drug Name

PF-4494700 Drug Info

Synonyms

PF-04494700; TTP-488; TTP-488); Alzheimers therapy, TransTech/Pfizer; Diabetic nephropathy therapy, Transtech/Pfizer; Alzheimer'streatment, TransTech/Pfizer; Alzheimer's therapy (RAGE), Transtech/Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 3	[1]
Dementia	6D80-6D86	Phase 3	[2]

Cross-matching ID

PubChem CID: 11180124
CAS Number: CAS 603148-36-3
TTD Drug ID: DMJ7IKW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Advanced glycosylation end product receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyridoxamine	DMVDCGZ	Diabetic kidney disease	GB61.Z	Phase 3	[4]
Alagebrium chloride	DMD741P	Hypotension	BA20-BA21	Phase 2/3	[5]
TTP-448	DMR37X8	Alzheimer disease	8A20	Phase 2	[3]
TTP-4000	DMCG01R	Alzheimer disease	8A20	Phase 1	[6]
DBT-066	DMFYCQ1	Dementia	6D80-6D86	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Advanced glycosylation end product receptor (AGER)	TTMO9HF	RAGE_HUMAN	Antagonist	[3]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8317).
3	Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9.
4	Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice. Protein Pept Lett. 2010 Sep;17(9):1177-81.
5	Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.
6	Receptor for advanced glycation end products: its role in Alzheimer's disease and other neurological diseases. Future Neurol. 2009; 4(2): 167-177.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843).