Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJBYSE)

• Drug Name: Nicotinamide riboside Drug Info
• Synonyms: nicotinamide riboside; nicotinamide ribose; nicotinamide-beta-riboside; nicotinamide ribonucleoside; N-ribosylnicotinamide; 1341-23-7; ribosylnicotinamide; 1-(beta-D-Ribofuranosyl)nicotinamide; UNII-0I8H2M0L7N; 0I8H2M0L7N; CHEBI:15927; 3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium; SRT647; SRT-647; SRT 647; N-ribosyl-nicotinamide; AC1L98BO; beta-nicotinamide D-riboside; SCHEMBL938611; N-Ribosyl-Nicotinamide New; Pyridinium, 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-; CHEMBL43849

Indication

Disease Entry	ICD 11	Status	REF
Mitochondrial myopathy	8C73	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 439924
  ChEBI ID: CHEBI:15927
  CAS Number: CAS 1341-23-7
  TTD Drug ID: DMJBYSE
  INTEDE Drug ID: DR1924

Molecule-Related Drug Atlas

Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[6]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[12]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Quinone reductase 2 (NQO2) Main DME	DEUATVX	NQO2_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Ribosyldihydronicotinamide dehydrogenase (NQO2)	OTGDAJRZ	NQO2_HUMAN	Biotransformations	[3]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Insights into the redox cycle of human quinone reductase 2. Free Radic Res. 2011 Oct;45(10):1184-95.
• [3] Old and new inhibitors of quinone reductase 2. Chem Biol Interact. 2010 Jul 30;186(2):103-9. doi: 10.1016/j.cbi.2010.04.006. Epub 2010 May 4.
• [4] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [5] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [6] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [7] Reduction and scavenging of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations. Chem Res Toxicol. 2018 Feb 19;31(2):116-126.
• [8] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [9] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [10] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [11] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [12] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [13] Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.