Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJD8XN)

• Drug Name: PHENIDONE Drug Info
• Synonyms: Phenidone; 92-43-3; 1-phenylpyrazolidin-3-one; 1-Phenyl-3-pyrazolidone; 1-PHENYL-3-PYRAZOLIDINONE; Fenidon; 3-Pyrazolidinone, 1-phenyl-; 1-Phenyl-3-oxopyrazolidine; 2-Pyrazolin-3-ol, 1-phenyl-; 1-P-3-P; Pyrazolidinone, 1-phenyl-; 1-Phenyl-pyrazolidin-3-one; UNII-H0U5612P6K; CCRIS 3624; 1-Phenylpyrazolid-3-one; EINECS 202-155-1; NSC 30306; 3-Pyrazolidinone,1-phenyl-; CHEMBL7660; 1-phenyl-4,5-dihydro-1H-pyrazol-3-ol; MLS002639322; CMCWWLVWPDLCRM-UHFFFAOYSA-N; H0U5612P6K; MFCD00003094; Phenidone A (1-Phenyl-3-pyrazolidinone)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 7090
  CAS Number: CAS 92-43-3
  TTD Drug ID: DMJD8XN

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[4]
Diethylcarbamazine	DM1TJ8F	Elephantiasis		Approved	[5]
Silymarin	DMXBYQR	N. A.	N. A.	Phase 4	[6]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[7]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[8]
ABT-761	DM3FIC2	Asthma	CA23	Phase 3	[9]
Tenidap	DMHQRYE	Rheumatoid arthritis	FA20	Phase 3	[10]
FPL-62064	DMGF8MZ	Inflammation	1A00-CA43.1	Phase 3	[11]
Flobufen	DMPSG4D	Rheumatoid arthritis	FA20	Phase 3	[12]
Darbufelone	DMYVKM5	Asthma	CA23	Phase 2/3	[13]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[14]
Naproxen	DMZ5RGV	Bursitis		Approved	[15]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[16]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[17]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[18]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[19]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[21]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[22]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[23]
Naproxen	DMZ5RGV	Bursitis		Approved	[15]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[24]
Indomethacin	DMSC4A7	Bursitis		Approved	[19]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[25]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[26]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[27]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[28]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[17]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[35]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[2]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Gene/Protein Processing	[3]

References

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