Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJI3BA)

Drug Name

Peginterferon alfa-2a Drug Info

Synonyms

Pegasys; Peginterferon alfa-2a (genetical recombination); Peginterferon alfa-2a (USAN/INN); Peginterferon alfa-2a (genetical recombination) (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Chronic hepatitis B virus infection		Approved	[1]
Hairy cell leukaemia	2A82.2	Approved	[2]
Leukemia		Approved	[3]

Therapeutic Class

Anticancer Agents

Cross-matching ID

TTD Drug ID: DMJI3BA
VARIDT Drug ID: DR00472

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon-alpha 2 (IFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Peginterferon alfa-2b	DMAP58Y	Hepatitis C virus infection	1E51.1	Approved	[4]
Interferon Alfa-2b	DMWCQP4	Melanoma	2C30	Approved	[4]
Albinterferon alfa-2b	DMK0QW6	Hepatitis C virus infection	1E51.1	Phase 3	[5]
Interferon alpha 2a	DMOTH6V	Hepatitis C virus infection	1E51.1	Phase 3	[6]
Hebergel	DMQTLVB	Virus infection	1A24-1D9Z	Phase 3	[7]
P-1101	DM7WYXJ	Essential thrombocythemia	3B63.1Z	Phase 3	[8]
Interferon alpha-2b	DMVACTU	Hepatitis C virus infection	1E51.1	Phase 2	[9]
Novaferon	DMEHOI1	Colorectal cancer	2B91.Z	Phase 2	[10]
Instiladrin	DMNKAFQ	Bladder cancer	2C94	Phase 2	[11]
CIGB-128	DMB2MKU	Basal cell carcinoma	2C32	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-alpha 2 (IFNA2)	TTSIUJ9	IFNA2_HUMAN	Modulator	[4]

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References

1	Entecavir and Peginterferon Alfa-2a in Adults With Hepatitis B e Antigen-Positive Immune-Tolerant Chronic Hepatitis B Virus Infection. Hepatology. 2019 Jun;69(6):2338-2348.
2	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3	Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med. 2010 Dec 23;363(26):2511-21.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009 Apr;25(4):991-1002.
6	Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. Blood. 1988 Aug;72(2):655-60.
7	Evaluation of recombinant human interferon alpha-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry. J Pharm Biomed Anal. 2006 Feb 24;40(3):781-7.
8	Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice. J Parasitol. 2010 Aug;96(4):703-8.
9	Clinical pipeline report, company report or official report of Avarx.
10	Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-alpha, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014; 14: 8.
11	ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health.
12	Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20.