Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJLNZQ)

Drug Name

K-828-AB Drug Info

Synonyms

GABA transaminase inhibitor (oral, dementia), Kowa

Indication

Disease Entry	ICD 11	Status	REF
Dementia	6D80-6D86	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[3]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[3]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[3]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[4]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[3]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[5]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[5]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[6]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[7]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of Kowa Co Ltd.
2	Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
3	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
4	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5	Clinical pipeline report, company report or official report of Catalyst Pharma.
6	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
7	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.