Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJSKUI)

• Drug Name: Norcisapride Drug Info
• Synonyms: Norcisapride; 84946-16-7; CHEMBL1748; 4-Amino-5-chloro-2-methoxy-N-(3-methoxy-4-piperidyl)benzamide; 4-amino-5-chloro-2-methoxy-N-(3-methoxy-4-piperidinyl)benzamide; (4-Amino-5-chloro-2-methoxy)-N-[3-methoxy(4-piperidyl)]benzamide; 4-amino-5-chloro-2-methoxy-N-(3-methoxypiperidin-4-yl)benzamide; Benzamide,4-amino-5-chloro-2-methoxy-N-[(3S,4R)-3-methoxy-4-piperidinyl]-, hydrochloride(1:1); EINECS 284-619-3; AC1MI81F; SCHEMBL593405; CTK4E8653; OMLDMGPCWMBPAN-UHFFFAOYSA-N; BDBM50301927; AKOS030254741; API0006151; DB-076176

Indication

Disease Entry	ICD 11	Status	REF
Gastroesophageal reflux disease	DA22.Z	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3019427
  CAS Number: CAS 84946-16-7
  TTD Drug ID: DMJSKUI
  INTEDE Drug ID: DR1780

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 4 receptor (HTR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisapride	DMY7PED	Gastroesophageal reflux disease	DA22.Z	Approved	[4]
Tegaserod	DM3XYD1	Irritable bowel syndrome	DD91.0	Approved	[5]
R0-93877	DMM4U9G	Constipation	DD91.1	Approved	[6]
HTF 919	DM78G6F	Constipation	DD91.1	Approved	[7]
Mosapride	DM2VOQ3	N. A.	N. A.	Phase 4	[8]
Renzapride	DM7HQNX	Irritable bowel syndrome	DD91.0	Phase 3	[9]
Lintopride	DMSHGWN	Nausea	MD90	Phase 2	[10]
TD-8954	DM3C9NV	Gastrointestinal disease	DE2Z	Phase 2	[11]
SB-207266A	DM27KFY	Irritable bowel syndrome	DD91.0	Phase 2	[6]
YKP-GI	DM740LV	Constipation	DD91.1	Phase 2	[12]

Drug(s) Targeting 5-HT 3A receptor (HTR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dolasetron	DMMG26Z	Nausea	MD90	Approved	[13]
Alosetron	DML2A03	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[14]
Tropisetron	DMNSJ7V	Fibromyalgia	MG30.01	Approved	[15]
Palonosetron	DMBHMOX	Nausea	MD90	Approved	[16]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[15]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[17]
Cilansetron	DMP0NGX	Irritable bowel syndrome	DD91.0	Phase 3	[18]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[19]
YM-114	DML2IXO	Nausea	MD90	Discontinued in Phase 2	[20]
ATI-17000	DMZJVR5	Irritable bowel syndrome	DD91.0	Preclinical	[5]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[28]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[32]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[33]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[35]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[36]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[37]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 3A receptor (HTR3A)	TTPC4TU	5HT3A_HUMAN	Inhibitor	[2]
5-HT 4 receptor (HTR4)	TT07C3Y	5HT4R_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Biotransformations	[3]

References

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