General Information of Drug (ID: DMK9NQI)

Drug Name
CPP-115 Drug Info
Synonyms
GABA aminotransferase inhibitors (oral), Northwestern University/Catalyst Pharmaceutical Partners; Vigabatrin derivatives (oral, neurological diseases), Northwestern University; Vigabatrin derivatives (oral, drug addiction/epilepsy/neuropathic pain), Catalyst Pharmaceutical Partners
Indication
Disease Entry ICD 11 Status REF
Tourette syndrome 8A05.00 Phase 2 [1]
Infantile spasm 8A62.0 Phase 1 [1]
Substance use disorder 6C4Z Phase 1 [2]
Cross-matching ID
PubChem CID
9794014
CAS Number
CAS 640897-20-7
TTD Drug ID
DMK9NQI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug(s) Targeting GABA transaminase (ABAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Alanine DMZDN4W Dietary shortage 5B5K Approved [4]
Pyridoxal Phosphate DMO2K0J Malnutrition 5B50-5B71 Approved [4]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [4]
Vigabatrin DMYT0OG Alcohol dependence 6C40.2 Approved [5]
Divalproex sodium DM4RK0G Seizure disorder 8A6Z Approved [4]
K-828-AB DMJLNZQ Dementia 6D80-6D86 Phase 2 [6]
CPP -15 DMQCHU3 Infantile spasm 8A62.0 Phase 1 [3]
T83193 DMHO29Y Discovery agent N.A. Patented [7]
4-hydroxybenzaldehyde DM471P5 Discovery agent N.A. Patented [8]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA transaminase (ABAT) TTT2LD9 GABT_HUMAN Inhibitor [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8284).
3 Clinical pipeline report, company report or official report of Catalyst Pharma.
4 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
5 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
6 Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
7 Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
8 Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.