Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKA705)

Drug Name

PGL-2001 Drug Info

Synonyms

Steroid sulfatase inhibitor (endometriosis), PregLem

Indication

Disease Entry	ICD 11	Status	REF
Endometriosis	GA10	Phase 2	[1]

Cross-matching ID

PubChem CID: 6918339
CAS Number: CAS 172377-52-5
TTD Drug ID: DMKA705

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tranilast	DME5Y64	Allergic rhinitis	CA08.0	Approved	[3]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[4]
STX-140	DMJK5CT	Osteoporosis	FB83.0	Phase 2	[5]
PGL-2	DMJTYO4	Endometriosis	GA10	Phase 2	[2]
STX 64	DMJAPRK	Prostate cancer	2C82.0	Phase 1	[6]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[7]
EMATE	DMFQX1U	Discovery agent	N.A.	Investigative	[8]
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester	DMM70K1	Discovery agent	N.A.	Investigative	[9]
Estradiol 17-O-sulfamate	DM7K14V	Discovery agent	N.A.	Investigative	[5]
4-Sulfamoyloxy-benzoic acid pentyl ester	DMZIFW7	Discovery agent	N.A.	Investigative	[10]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steryl-sulfatase (STS)	TTHM0R1	STS_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT01631981) PGL2001 Proof of Concept Study in Symptomatic Endometriosis. U.S. National Institutes of Health.
2	Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65.
3	Review of estrone sulfatase and its inhibitors--an important new target against hormone dependent breast cancer. Curr Med Chem. 2002 Jan;9(2):263-73.
4	Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70.
5	2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96.
6	Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin Cancer Res. 2006 Mar 1;12(5):1585-92.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8	Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6.
9	Estrogenic potential of 2-alkyl-4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase. J Med Chem. 2003 Nov 6;46(23):5091-4.
10	Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9.