Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKDGLA)

• Drug Name: LP-211 Drug Info
• Synonyms: compound 25 [PMID 18800769]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25107716
  CAS Number: CAS 1052147-86-0
  TTD Drug ID: DMKDGLA

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[2]
Haloperidol	DM96SE0	Delirium		Approved	[3]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[4]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[5]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[6]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[7]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[8]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[9]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[10]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[11]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[12]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[13]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[14]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[15]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[16]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[17]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[18]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[19]
Treximet	DMU54QB	Migraine	8A80	Approved	[20]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[21]

Drug(s) Targeting 5-HT 7 receptor (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[22]
JNJ-18038683	DMV1T59	Major depressive disorder	6A70.3	Phase 2	[23]
AVN-101	DMOGFNI	Cognitive impairment	6D71	Phase 2	[24]
ATI-9242	DM6GKMU	Schizophrenia	6A20	Phase 1	[25]
PMID30124346-Compound-34TABLE4	DM2G3VE	Attention deficit hyperactivity disorder	6A05.Z	Patented	[26]
PMID30124346-Compound-13TABLE4	DMHTJVA	Attention deficit hyperactivity disorder	6A05.Z	Patented	[26]
Carbamide derivative 2	DMW5GI3	N. A.	N. A.	Patented	[27]
4-oxadiazole derivative 1	DMWFHKR	N. A.	N. A.	Patented	[27]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[28]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[29]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Agonist	[1]
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Agonist	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[1]

References

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• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639).
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• [9] [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1.
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• [13] Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
• [14] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
• [15] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [16] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [17] Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
• [18] Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
• [19] Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
• [20] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [21] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
• [22] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [23] Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2015 Jan 15;8:453.
• [24] AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53(2):583-620.
• [25] Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12.
• [26] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [27] Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
• [28] [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. Br J Pharmacol. 2000 May;130(2):409-17.
• [29] Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.