Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKVP7E)

Drug Name

Apolizumab Drug Info

Synonyms

Remitogen; Hu 1D10; Hu1D10, PDL; SMART 1D10 MAb, Protein Design Labs; SMART anti-B cell lymphoma

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting MHC class II antigen DR (HLA-DR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AEA-35p	DMQRKXP	Influenza virus infection	1E30-1E32	Phase 1	[3]
IMMU-114	DMTFUM4	Haematological malignancy	2B33.Y	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MHC class II antigen DR (HLA-DR)	TTYA75N	DRA_HUMAN; 2B1F_HUMAN; DRB3_HUMAN; DRB4_HUMAN; DRB5_HUMAN	Modulator	[2]

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References

1	A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia. Leuk Lymphoma. 2009 Dec;50(12):1958-63.
2	A humanized HLA-DR antibody (hu1D10, apolizumab) in combination with granulocyte colony-stimulating factor (filgrastim) for the treatment of non-Hodgkin's lymphoma: a pilot study.
3	WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
4	The humanized anti-HLA-DR moAb, IMMU-114, depletes APCs and reduces alloreactive T cells: implications for preventing GVHD. Bone Marrow Transplant. 2012 Jul;47(7):967-80.