Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML4P6O)

Drug Name

A-313326 Drug Info

Synonyms

CHEMBL41748; A-313326; SCHEMBL7083765; BDBM13389; A313326; 4-[alpha-(1-Methyl-1H-imidazole-5-yl)-3-(1-naphthyl)-4-cyanobenzyloxymethyl]benzonitrile

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23646371
TTD Drug ID: DML4P6O

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Geranylgeranyl transferase I (GGTase-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-778123	DMWSC5L	Lymphoma	2A80-2A86	Phase 1	[2]
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
GGTI-298	DM1CG0J	N. A.	N. A.	Terminated	[4]
PD-83176	DMSIMKZ	Discovery agent	N.A.	Investigative	[5]
J-109,390	DM9SFGB	Discovery agent	N.A.	Investigative	[6]
L-269,289	DMV6018	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Targeting CAAX farnesyltransferase beta (FNTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
ABT-839	DM4UN9A	Non-small-cell lung cancer	2C25.Y	Terminated	[1]
MANUMYCIN A	DM1SWOY	N. A.	N. A.	Terminated	[7]
SCH-44342	DMUL4VX	N. A.	N. A.	Terminated	[3]
RPR-113829	DMJ63GW	N. A.	N. A.	Terminated	[8]
RPR-114334	DMAIJT6	N. A.	N. A.	Terminated	[8]
L-731735	DM1XBKC	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
FUSIDIENOL	DMI1Y92	N. A.	N. A.	Terminated	[9]
ABT-100	DMPFLS5	Solid tumour/cancer	2A00-2F9Z	Terminated	[10]
B-956	DM1IO9X	Solid tumour/cancer	2A00-2F9Z	Terminated	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CAAX farnesyltransferase beta (FNTB)	TT7WZIJ	FNTB_HUMAN	Inhibitor	[1]
Geranylgeranyl transferase I (GGTase-I)	TTX20QP	PGTB1_HUMAN	Inhibitor	[1]

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References

1	Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.
2	Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein trans... Mol Cancer Ther. 2002 Jul;1(9):747-58.
3	Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90.
4	The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J Biol Chem. 1997 Oct 24;272(43):27224-9.
5	Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem. 1997 Jan 17;40(2):192-200.
6	Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes. J Bacteriol. 2000 Feb;182(3):704-13.
7	A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6.
8	Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7.
9	Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem. 2002 Mar 28;45(7):1460-5.
10	Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9.
11	Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 1995 Nov 15;55(22):5310-4.