Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLDZX1)

Drug Name

PfAMA-1 Drug Info

Synonyms

PfAMA-1-FVO[25-545]; Apical membrane antigen 1 vaccine (Plasmodium infection), African Malaria Network Trust/European Malaria Vaccine Initiative/Biomedical Primate Research Centre; AMA-1 vaccine (malaria), AMANET/EMVI/BPRC

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMLDZX1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Plasmodium Apical membrane protein (Malaria AMA-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AdCh63 AMA1	DMEGPSW	Malaria	1F40-1F45	Phase 1/2	[3]
DNA-Ad	DM71BFM	Malaria	1F40-1F45	Phase 1/2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Apical membrane protein (Malaria AMA-1)	TTQZW34	AMA1_PLAFF	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00431808) Safety and Immunogenicity of Apical Membrane Antigen 1 (PfAMA-1-FVO[25-545]). U.S. National Institutes of Health.
2	Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite devel... J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34.
3	ClinicalTrials.gov (NCT01142765) Study to Assess Efficacy of New Malaria Vaccine Candidates AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP & MVA ME-TRAP. U.S. National Institutes of Health.
4	Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One. 2014 Sep 11;9(9):e106241.