Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM45P9)

Drug Name

Ad-IFN-alpha Drug Info

Synonyms

Ad-IFN-alpha (cancer); Ad-IFN-alpha (cancer), MD Anderson Cancer Center/NCI; Adenoviral-mediated IFN-alpha (gene therapy, cancer), MD Anderson Cancer Center/NCI

Indication

Disease Entry	ICD 11	Status	REF
Bladder cancer	2C94	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMM45P9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon alpha (IFNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Interferon alfa-n3	DMTZNQ9	Human immunodeficiency virus infection	1C62	Approved	[2]
Alfaferone	DMCKPUR	Hairy cell leukaemia	2A82.2	Approved	[3]
P1101	DM5DRMY	Polycythemia vera	2A20.4	Phase 3	[4]
Human interferon alpha oral	DMKQ3MC	Hepatitis C virus infection	1E51.1	Phase 2	[5]
IFN-alpha	DM4H8EZ	Hepatitis C virus infection	1E51.1	Phase 2	[6]
Rontalizumab	DMBJN19	Systemic lupus erythematosus	4A40.0	Phase 2	[7]
Interferon-alpha lozenge	DM8YF01	Behcet disease	4A62	Phase 2	[8]
IFN alpha kinoid	DMLEVFW	Human immunodeficiency virus infection	1C62	Phase 1/2	[9]
NG-641	DMITVHM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
AGS-009	DMU21JF	Systemic lupus erythematosus	4A40.0	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon alpha (IFNA)	TT95SOA	NOUNIPROTAC	Modulator	[1]

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References

1	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2	Clinical pipeline report, company report or official report of Hemispherx Biopharma.
3	Natural leukocyte interferon alpha (Alfaferone) combined with ribavirin in the treatment of patients with HCV-related cirrhosis: our experience. Infection. 2011 Oct;39(5):433-7.
4	Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. Am J Hematol. 2015 Apr;90(4):288-94.
5	Low-dose oral natural human interferon-alpha in 29 patients with HIV-1 infection: a double-blind, randomized, placebo-controlled trial. AIDS. 1992 Jun;6(6):563-9.
6	WO patent application no. 2009,0153,36, Controlled release interferon drug products and treatment of hcv infection using same.
7	Clinical pipeline report, company report or official report of Genentech (2011).
8	Interferon-alpha. Amarillo Biosciences. Curr Opin Investig Drugs. 2002 May;3(5):693-7.
9	Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoid. Arthritis Rheum. 2013 Feb;65(2):447-56.
10	Clinical pipeline report, company report or official report of PsiOxus Therapeutics.
11	Emerging Therapies for Systemic Lupus Erythematosus - Focus on Targeting Interferon-alpha. Clin Immunol. 2012 June; 143(3): 210-221.