Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM7TBO)

Drug Name
MORAb-022 Drug Info
Synonyms Antibody (inflammation/autoimmune disease), Morphotek
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 1 [1]
Rheumatoid arthritis FA20 Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMM7TBO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talimogene Laherparepvec DMKBW5C Melanoma 2C30 Approved [4]
Lenzilumab DMSRIT4 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 Trial [5]
JX-594 DM5WCV4 Hepatocellular carcinoma 2C12.02 Phase 3 [6]
Mavrilimumab DMMVFRC Rheumatoid arthritis FA20 Phase 2 [2]
Cabiralizumab DMGE058 Pancreatic cancer 2C10 Phase 2 [5]
KB002/003 DM60G5O Rheumatoid arthritis FA20 Phase 2 [7]
GSK3196165 DMEXKF4 Rheumatoid arthritis FA20 Phase 2 [2]
KB-003 DM74KIM Severe asthma CA23 Phase 2 [8]
MT203 DM7I0MT Plaque psoriasis EA90.0 Phase 2 [9]
Autologous melanoma cell vaccine DMARYFK Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte-macrophage colony-stimulating factor (CSF2) TTNYZG2 CSF2_HUMAN Not Available [3]
Immunoglobulin gamma-1 heavy NIE (NIE) TT0T5HK IGG1_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT01357759) Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Morphotek.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF. Mol Ther. 2006 Sep;14(3):361-70.
7 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
8 US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.
9 GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential. Expert Rev Clin Immunol. 2015 Apr;11(4):457-65.