Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMBC5W)

Drug Name

PDGF-BB Drug Info

Synonyms

PDGF-BB (BioChaperone technology, diabetic foot ulcer/venous ulcers/burns)

Indication

Disease Entry	ICD 11	Status	REF
Diabetic foot ulcer	BD54	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Platelet-derived growth factor B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-10030	DMDYWM8	Macular degeneration	9B78.3	Phase 2	[3]
GAM-501	DMAEWS1	Diabetic foot ulcer	BD54	Phase 2	[4]
CR-002	DMKWSFI	Cystic fibrosis	CA25	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-derived growth factor B (PDGFB)	TTQA6SX	PDGFB_HUMAN	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5039).
2	Clinical pipeline report, company report or official report of Adocia.
3	Aptamers as therapeutics. Nat Rev Drug Discov. 2010 Jul;9(7):537-50.
4	Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial. Wound Repair Regen. 2009 Nov-Dec;17(6):772-9.
5	A phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D. Int J Clin Pharmacol Ther. 2008 May;46(5):236-44.