Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMXFBJ)

Drug Name
dATP Drug Info
Synonyms deoxyadenosine triphosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15993
ChEBI ID
CHEBI:16284
CAS Number
CAS 1927-31-7
TTD Drug ID
DMMXFBJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting P2Y purinoceptor 11 (P2RY11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
INS 316 DMTHMEI Lung cancer 2C25.0 Discontinued in Phase 3 [3]
2MeSATP DMUE0W6 Discovery agent N.A. Investigative [2]
BzATP DM37GYA Discovery agent N.A. Investigative [2]
ATPgammaS DMXHQIN Discovery agent N.A. Investigative [2]
NAADP DM51DW6 Discovery agent N.A. Investigative [4]
NF546 DMPZB31 Discovery agent N.A. Investigative [5]
NF157 DMGMH8T Discovery agent N.A. Investigative [6]
NF340 DMPSXR8 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 11 (P2RY11) TTYXPCO P2Y11_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1760).
2 Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.
3 Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling. Mol Pharmacol. 2003 Jun;63(6):1356-63.
4 NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008 Apr;43(4):344-55.
5 NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47.
6 Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48(22):7040-8.
7 Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal. 2006 May;2(1):1-324.