Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN2XTQ)

Drug Name

B173 Drug Info

Synonyms

BRL 54443 maleate; BRL 54443 maleate salt; 1197333-54-2; EU-0100207; 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol maleate; SCHEMBL4799792; CHEMBL1256797; MolPort-003-940-420; BRL 54443 maleate salt, solid; HMS3260J15; Tox21_500207; BN0117; LP00207; CCG-221511; NCGC00093680-01; NCGC00260892-01; B-173; SR-01000075573-1; J-004192; 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol maleate salt

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11957480
TTD Drug ID: DMN2XTQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting 5-HT 1E receptor (HTR1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[2]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[2]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[2]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[3]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[4]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[2]
m-chlorophenylpiperazine	DMM1J2D	Discovery agent	N.A.	Investigative	[2]
EDMT	DMS3AXK	Discovery agent	N.A.	Investigative	[5]
9-OH-risperidone	DMGORXQ	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1E receptor (HTR1E)	TTCPG9S	5HT1E_HUMAN	Agonist	[1]

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References

1	The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol Clin Exp Res. 2007 Jan;31(1):11-8.
2	Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39.
3	SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
4	Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
5	2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.
6	Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73.