Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNBUS7)

Drug Name

Rozrolimupab Drug Info

Synonyms

SYM-001; Symphoglobulin-D; Recombinant human polyclonal antibodies (rhesus D), Symphogen/Biovitrum; Recombinant polyclonal antibodies (idiopathic thrombocytopenic purpura), Symphogen/Biovitrum; Symphobodies (hemolytic disease of the newborn), Symphogen/Biovitrum; Anti-RhD (trombocytopeni, anti-D-profylax), Symphogen/Biovitrum

Indication

Disease Entry	ICD 11	Status	REF
Anemia	3A00-3A9Z	Discontinued in Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMNBUS7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Blood group Rh(D) polypeptide (RHD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Roledumab	DMWZ6DK	Anemia	3A00-3A9Z	Phase 2/3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Blood group Rh(D) polypeptide (RHD)	TTLCKI8	RHD_HUMAN	Not Available	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025976)
2	Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura. Curr Opin Mol Ther. 2010 Dec;12(6):734-40.
3	Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22.