Details of the Drug

General Information of Drug (ID: DMNBUS7)

Drug Name

Rozrolimupab

Synonyms

SYM-001; Symphoglobulin-D; Recombinant human polyclonal antibodies (rhesus D), Symphogen/Biovitrum; Recombinant polyclonal antibodies (idiopathic thrombocytopenic purpura), Symphogen/Biovitrum; Symphobodies (hemolytic disease of the newborn), Symphogen/Biovitrum; Anti-RhD (trombocytopeni, anti-D-profylax), Symphogen/Biovitrum

Indication

Disease Entry	ICD 11	Status	REF
Anemia	3A00-3A9Z	Discontinued in Phase 2	[1]
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Drug Type

Antibody

Cross-matching ID

UNII: S134V96RPQ
DrugBank ID: DB05209
TTD ID: D06UPS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Blood group Rh(D) polypeptide (RHD)	TTLCKI8	RHD_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Anemia

ICD Disease Classification

3A00-3A9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Blood group Rh(D) polypeptide (RHD)	DTT	RHD	4.18E-02	0.64	1.13

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025976)
2	Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura. Curr Opin Mol Ther. 2010 Dec;12(6):734-40.