Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNST69)

• Drug Name: Metaiodobenzylguanidine I-131 Drug Info
• Synonyms: Azedra (TN)

Indication

Disease Entry	ICD 11	Status	REF
Neuroblastoma	2D11.2	Phase 2	[1]
Neuroendocrine cancer	2B72.1	Phase 2	[2]
Pheochromocytoma	5A75	Application submitted	[3]

• Cross-matching ID:
  PubChem CID: 71184
  ChEBI ID: CHEBI:135997
  CAS Number: CAS 77679-27-7
  TTD Drug ID: DMNST69

Molecule-Related Drug Atlas

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[6]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[7]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[5]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[8]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[9]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[10]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[9]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[11]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Modulator	[4]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004852)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91.
• [5] Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107.
• [6] Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6.
• [7] Invivo antioxidant status: a putative target of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):220-8.
• [8] Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
• [9] Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.
• [10] 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
• [11] Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol. 2006 Oct;16(7):481-90.
• [12] Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42.