Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO1VHC)

Drug Name
ALX-0061 Drug Info
Synonyms Nanobody therapeutic (autoimmune/inflammatory disease), Ablynx; Anti-IL-6R nanobody therapeutic (autoimmune/inflammatory disease), Ablynx
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 2 [1]
Rheumatoid arthritis FA20 Phase 2 [2]
Systemic lupus erythematosus 4A40.0 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMO1VHC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Interleukin 6 receptor (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tocilizumab DM7J6OR Giant cell arteritis 4A44.2 Approved [4]
Sarilumab DMOGNXY Rheumatoid arthritis FA20 Approved [5]
Sirukumab DMK8AQP Cutaneous lupus erythematosus EB5Z Phase 3 [6]
SAR153191 DMXAO4J Ankylosing spondylitis FA92.0 Phase 3 [7]
SA-237 DM7F2VG Encephalopathy 8E47 Phase 3 [8]
Vobarilizumab DM9KNJT Rheumatoid arthritis FA20 Phase 2 [9]
SBP-002 DM9F7R0 Melanoma 2C30 Terminated [5]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [10]
FM-101 DMXK6EI Multiple myeloma 2A83 Investigative [6]
Sant7 DM9CV4P Multiple myeloma 2A83 Investigative [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 6 receptor (IL6R) TT0E5SK IL6RA_HUMAN; IL6RB_HUMAN Not Available [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8363).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 The preclinical pharmacology of the high affinity anti-IL-6R Nanobody ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther. 2015 May 20;17:135.
4 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2310).
7 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
8 IBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics International Conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA. MAbs. 2013 March 1; 5(2): 178-201.
9 Clinical pipeline report, company report or official report of Ablynx.
10 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.