Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO6Z02)

Drug Name

Di(2,6-di-t-butylphenol) Drug Info

Synonyms

128-38-1; Ethyl 712; 3,3',5,5'-Tetra-tert-butylbiphenyl-4,4'-diol; UNII-D85N5VOL1N; 3,3',5,5'-tetra(tert-butyl)[1,1'-biphenyl]-4,4'-diol; D85N5VOL1N; CHEMBL1662; 4,4-Bis(2,6-di-tert-butylphenol); [1,1'-Biphenyl]-4,4'-diol, 3,3',5,5'-tetrakis(1,1-dimethylethyl)-; 3,3',5,5'-Tetra-tert-butyl-[1,1'-biphenyl]-4,4'-diol; Inter008513,3',5,5'-Tetra-tert-butyl-4,4'-dihydroxybiphenyl; 2,6-bis(tert-butyl)-4-[3,5-bis(tert-butyl)-4-hydroxyphenyl]phenol; 4, 3,3',5,5'-tetra-tert-butyl-; [1,4'-diol, 3,3',5,5'-tetrakis(1,1-dimethylethyl

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 67185
CAS Number: CAS 128-38-1
TTD Drug ID: DMO6Z02

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[4]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[5]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[6]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[6]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[7]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[8]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[9]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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References

1	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11.
2	Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
3	Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
4	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
5	Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
7	Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
8	Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
9	Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
10	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.