Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOH2VC)

Drug Name

PSB-1115 Drug Info

Synonyms

PSB 1115; 152529-79-8; PSB-1115; CHEMBL8565; 4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid; 4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID; 4-(2,6-dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid; 1-propyl-8-p-sulfophenylxanthine; PSB1115; AC1NSKPC; Tocris-2009; compound 17 [PMID: 11906291]; GTPL3286; SCHEMBL1223271; CHEBI:92848; DTXSID80415532; MolPort-003-983-852; ZINC3995486; 1-Propyl-8-(p-sulfophenyl)xanthine; BN0664; BDBM50042209

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311479
ChEBI ID: CHEBI:92848
CAS Number: CAS 152529-79-8
TTD Drug ID: DMOH2VC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[3]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[3]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[4]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[5]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[6]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[7]
KF-17837	DMQ6DLZ	Parkinson disease	8A00.0	Phase 1	[8]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[9]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[10]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[7]
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Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[11]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[12]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[5]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[13]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[14]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[15]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[16]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[14]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[17]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[18]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[2]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3286).
2	1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of Klus Pharma
5	2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203.
6	Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem. 1993 Nov 12;36(23):3731-3.
9	Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6.
10	GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.
11	Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.
12	Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009 Aug 17;117(7):265-72.
13	Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53.
14	Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308.
15	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)
16	Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart. Clin Sci (Lond). 2009 Jul 16;117(4):157-64.
17	A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10.
18	Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Current Issue vol. 111 no. 12 Celine Valant, 4614-4619.