Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOHB3Z)

• Drug Name: 8-sulfophenyl theophylline Drug Info
• Synonyms: 8-(p-Sulfophenyl)theophylline; 8-(4-Sulfophenyl)theophylline; 80206-91-3; 8-SPT; 4-(1,3-dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)benzenesulfonic acid; CHEMBL8488; Psp-theophylline; 8-Sulphophenyltheophylline; Lopac-A-013; AC1Q6X0T; AC1L1CI3; Lopac0_000135; 8-(P-Sulfophenyl)Thiophylline; SCHEMBL1320226; 8-(p-Sulfophenyl)-theophylline; CTK6I1750; BDBM82023; CTK3E8290; DTXSID90230152; LXJSJIXZOAMHTG-UHFFFAOYSA-N; MolPort-006-068-692; HMS3260K12; ALBB-009371; ZX-AN008233; ZINC5322904; NSC_1908; Tox21_500135; PDSP1_000449

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1908
  CAS Number: CAS 80206-91-3
  TTD Drug ID: DMOHB3Z

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine receptor (ADOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[3]
NIR178	DMPER4A	Non-hodgkin lymphoma	2B33.5	Phase 2	[4]
DIADENOSINE TETRAPHOSPHATE	DMTJOEL	Cardiac arrhythmias	BC9Z	Phase 2	[5]
M-216765	DMUIGM3	Hypertension	BA00-BA04	Terminated	[6]
GNF-PF-2224	DM26UKN	Discovery agent	N.A.	Investigative	[1]
SPT	DM94RJW	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[8]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[12]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[13]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[25]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[21]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[22]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine receptor (ADOR)	TTSLI08	NOUNIPROTAC	Antagonist	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[2]
Interleukin-13 (IL13)	OTI4YS3Y	IL13_HUMAN	Protein Interaction/Cellular Processes	[2]

References

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• [14] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
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• [16] Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
• [17] Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
• [18] Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells. J Biochem Mol Toxicol. 2018 Jun;32(6):e22054.
• [19] Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
• [20] Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
• [21] Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
• [22] Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
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